Department of Medical Laboratory Sciences, Faculty of Allied Health Sciences-Kuwait University, Sulaibekhat, Kuwait.
J Hum Genet. 2010 Apr;55(4):232-5. doi: 10.1038/jhg.2010.11. Epub 2010 Mar 12.
Factor V Leiden (FVL) mutation (G1691A) is a risk factor for development of venous thromboembolic disorders. FVL was found mostly in Caucasians (1-15%) but was almost absent in non-Caucasians. Studies on Arab patients and populations revealed very inconsistent results. This study reports FVL in Arabs living in Kuwait with a focus on the nationality of the Arab subjects studied. Whole-blood samples were collected from 400 healthy Arabs who were 268 Kuwaitis (67%), 50 Syrians (12.5%), 34 Jordanians (8.5%), 8 Palestinians (2%) and 40 Egyptians (10%). DNA extraction was carried out for these blood samples and real-time PCR was performed to detect the presence of FVL. Generally, 36 cases (9%) had the mutation (33 were heterozygous and 3 were homozygous), with an allelic frequency of 0.049. The prevalence of FVL differed in different Arabic cases: Kuwaitis 4.5%, Egyptians 15%, Syrians 16%, Jordanians 23.5% and Palestinians 25%. The allelic frequency was 0.022 in the Kuwaitis and 0.088-0.132 in non-Kuwaitis. The three homozygous cases were from Syria, Jordan and Egypt. In conclusion, the prevalence of FVL in Arabs living in Kuwait is as high as in Caucasians. There is a difference in prevalence among Arabs themselves, being relatively lower in Kuwaitis than in non-Kuwaitis.
凝血因子 V 莱顿（FVL）突变（G1691A）是静脉血栓栓塞性疾病发展的一个风险因素。FVL 主要见于白种人（1-15%），但在非白种人中几乎不存在。针对阿拉伯患者和人群的研究结果差异很大。本研究报告了居住在科威特的阿拉伯人的 FVL 情况，重点关注所研究的阿拉伯受试者的国籍。从 400 名健康的阿拉伯人采集全血样本，其中 268 名为科威特人（67%），50 名为叙利亚人（12.5%），34 名为约旦人（8.5%），8 名为巴勒斯坦人（2%），40 名为埃及人（10%）。对这些血液样本进行 DNA 提取，并进行实时 PCR 检测以检测 FVL 的存在。总体而言，有 36 例（9%）存在突变（33 例为杂合子，3 例为纯合子），等位基因频率为 0.049。不同阿拉伯病例的 FVL 患病率不同：科威特人为 4.5%，埃及人为 15%，叙利亚人为 16%，约旦人为 23.5%，巴勒斯坦人为 25%。科威特人的等位基因频率为 0.022，非科威特人的等位基因频率为 0.088-0.132。3 例纯合子病例来自叙利亚、约旦和埃及。总之，居住在科威特的阿拉伯人中 FVL 的患病率与白种人相当。阿拉伯人之间存在差异，科威特人的患病率相对低于非科威特人。
