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1
Expression of pigment epithelium-derived factor in human melanocytes and malignant melanoma cells and tissues: Is loss of pigment epithelium-derived factor associated with melanoma?色素上皮衍生因子在人黑素细胞、恶性黑色素瘤细胞及组织中的表达：色素上皮衍生因子的缺失与黑色素瘤有关吗？
Dermatoendocrinol. 2009 Mar;1(2):108-13. doi: 10.4161/derm.1.2.7668.
2
A novel role for microphthalmia-associated transcription factor-regulated pigment epithelium-derived factor during melanoma progression.小眼畸形相关转录因子调控的色素上皮衍生因子在黑色素瘤进展过程中的新作用。
Am J Pathol. 2015 Jan;185(1):252-65. doi: 10.1016/j.ajpath.2014.09.012. Epub 2014 Nov 6.
3
Overexpression of pigment epithelium-derived factor decreases angiogenesis and inhibits the growth of human malignant melanoma cells in vivo.色素上皮衍生因子的过表达可减少血管生成并在体内抑制人恶性黑色素瘤细胞的生长。
Am J Pathol. 2004 Apr;164(4):1225-32. doi: 10.1016/s0002-9440(10)63210-5.
4
Gene expression of the neurotrophic pigment epithelium-derived factor in the human ciliary epithelium. Synthesis and secretion into the aqueous humor.神经营养性色素上皮衍生因子在人睫状体上皮中的基因表达。其合成及向房水的分泌。
Invest Ophthalmol Vis Sci. 1996 Dec;37(13):2759-67.
5
Loss of pigment epithelium derived factor expression in glioma progression.色素上皮衍生因子表达缺失在胶质瘤进展中的作用
J Clin Pathol. 2003 Apr;56(4):277-82. doi: 10.1136/jcp.56.4.277.
6
[Downregulation of the pigment epithelium derived factor by hypoxia and elevated glucose concentration in cultured human retinal pigment epithelial cells].[缺氧和高糖浓度对培养的人视网膜色素上皮细胞中色素上皮衍生因子的下调作用]
Zhonghua Yi Xue Za Zhi. 2003 Nov 25;83(22):1989-92.
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Pigment epithelium-derived factor as a new diagnostic marker for melanocytic tumors.
Kurume Med J. 2005;52(3):81-7. doi: 10.2739/kurumemedj.52.81.
8
Expression of pigment epithelium-derived factor in normal adult rat eye and experimental choroidal neovascularization.色素上皮衍生因子在正常成年大鼠眼及实验性脉络膜新生血管中的表达
Invest Ophthalmol Vis Sci. 2002 Apr;43(4):1168-75.
9
Pigment epithelium-derived factor is a substrate for matrix metalloproteinase type 2 and type 9: implications for downregulation in hypoxia.色素上皮衍生因子是基质金属蛋白酶2型和9型的作用底物：对缺氧下调的影响。
Invest Ophthalmol Vis Sci. 2005 Aug;46(8):2736-47. doi: 10.1167/iovs.04-1489.
10
Phosphomimetic mutants of pigment epithelium-derived factor with enhanced anti-choroidal melanoma cell activity in vitro and in vivo.具有增强的体外和体内抗脉络膜黑色素瘤细胞活性的色素上皮衍生因子磷酸模拟突变体。
Invest Ophthalmol Vis Sci. 2012 Oct 3;53(11):6793-802. doi: 10.1167/iovs.12-10326.

引用本文的文献

1
Impact of pigment epithelium-derived factor on colorectal cancer and .色素上皮衍生因子对结直肠癌的影响及…… （原文似乎不完整）
Oncotarget. 2018 Apr 10;9(27):19192-19202. doi: 10.18632/oncotarget.24953.
2
Effect of adiponectin on expression of vascular endothelial growth factor and pigment epithelium-derived factor: an in vitro study.脂联素对血管内皮生长因子和色素上皮衍生因子表达的影响：一项体外研究。
Indian J Pharmacol. 2015 Jan-Feb;47(1):117-20. doi: 10.4103/0253-7613.150376.
3
Systemically administered liposome-encapsulated Ad-PEDF potentiates the anti-cancer effects in mouse lung metastasis melanoma.系统给予脂质体包裹的 Ad-PEDF 可增强小鼠肺转移黑色素瘤的抗癌作用。
J Transl Med. 2013 Apr 3;11:86. doi: 10.1186/1479-5876-11-86.

本文引用的文献

1
Angiogenesis and metastasis inhibitors for the treatment of malignant melanoma.用于治疗恶性黑色素瘤的血管生成和转移抑制剂。
Mini Rev Med Chem. 2007 Jun;7(6):649-61. doi: 10.2174/138955707780859440.
2
PEDF: a potential molecular therapeutic target with multiple anti-cancer activities.色素上皮衍生因子：一种具有多种抗癌活性的潜在分子治疗靶点。
Trends Mol Med. 2006 Oct;12(10):497-502. doi: 10.1016/j.molmed.2006.08.009. Epub 2006 Sep 7.
3
Pigment epithelium-derived factor targets endothelial and epithelial cells in Wilms' tumor.色素上皮衍生因子作用于肾母细胞瘤中的内皮细胞和上皮细胞。
J Pediatr Surg. 2006 Aug;41(8):1351-6. doi: 10.1016/j.jpedsurg.2006.04.038.
4
A PEDF N-terminal peptide protects the retina from ischemic injury when delivered in PLGA nanospheres.当通过聚乳酸-羟基乙酸共聚物（PLGA）纳米球递送时，PEDF N端肽可保护视网膜免受缺血性损伤。
Exp Eye Res. 2006 Oct;83(4):824-33. doi: 10.1016/j.exer.2006.04.014. Epub 2006 Jul 5.
5
Pigment epithelium-derived factor is estrogen sensitive and inhibits the growth of human ovarian cancer and ovarian surface epithelial cells.色素上皮衍生因子对雌激素敏感，并能抑制人卵巢癌及卵巢表面上皮细胞的生长。
Endocrinology. 2006 Sep;147(9):4179-91. doi: 10.1210/en.2006-0168. Epub 2006 Jun 15.
6
Angiostatin decreases cell migration and vascular endothelium growth factor (VEGF) to pigment epithelium derived factor (PEDF) RNA ratio in vitro and in a murine ocular melanoma model.血管抑素在体外及小鼠眼黑色素瘤模型中可降低细胞迁移以及血管内皮生长因子（VEGF）与色素上皮衍生因子（PEDF）的RNA比值。
Mol Vis. 2006 May 22;12:511-7.
7
Pigment-epithelium-derived factor (PEDF) inhibits angiotensin-II-induced vascular endothelial growth factor (VEGF) expression in MOLT-3 T cells through anti-oxidative properties.色素上皮衍生因子（PEDF）通过抗氧化特性抑制血管紧张素II诱导的MOLT-3 T细胞中血管内皮生长因子（VEGF）的表达。
Microvasc Res. 2006 May;71(3):222-6. doi: 10.1016/j.mvr.2006.03.001. Epub 2006 Apr 19.
8
Expression of pigment epithelial derived factor is reduced in non-small cell lung cancer and is linked to clinical outcome.色素上皮衍生因子在非小细胞肺癌中的表达降低，并与临床预后相关。
Int J Mol Med. 2006 May;17(5):937-44.
9
Pigment epithelium-derived factor (PEDF)-induced apoptosis and inhibition of vascular endothelial growth factor (VEGF) expression in MG63 human osteosarcoma cells.色素上皮衍生因子（PEDF）诱导MG63人骨肉瘤细胞凋亡并抑制血管内皮生长因子（VEGF）表达。
Life Sci. 2005 Nov 4;77(25):3231-41. doi: 10.1016/j.lfs.2005.05.048. Epub 2005 Jun 27.
10
Inhibition of xenografted human melanoma growth and prevention of metastasis development by dual antiangiogenic/antitumor activities of pigment epithelium-derived factor.色素上皮衍生因子的双重抗血管生成/抗肿瘤活性对异种移植人黑色素瘤生长的抑制及转移发展的预防作用
Cancer Res. 2004 Aug 15;64(16):5632-42. doi: 10.1158/0008-5472.CAN-04-0230.

色素上皮衍生因子在人黑素细胞、恶性黑色素瘤细胞及组织中的表达：色素上皮衍生因子的缺失与黑色素瘤有关吗？

Expression of pigment epithelium-derived factor in human melanocytes and malignant melanoma cells and tissues: Is loss of pigment epithelium-derived factor associated with melanoma?

作者信息

Zhang Cheng-Feng, Xiang Lei-Hong, Shen Jie, Zhang Yong, Li Jian, Zheng Zhi-Zhong

出版信息

Dermatoendocrinol. 2009 Mar;1(2):108-13. doi: 10.4161/derm.1.2.7668.

DOI:10.4161/derm.1.2.7668
PMID:20224693
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2835900/
Abstract

BACKGROUND

Pigment epithelium-derived factor (PEDF) was first isolated from the medium conditioned by human fetal retinal pigment epithelial cells and has been detected in a broad range of human fetal and adult tissues. Recent studies have indicated that PEDF activity is inhibitory to angiogenesis.

OBJECTIVE

To study the expression and distribution of pigment epithelium-derived factor (PEDF) in human melanocytes, malignant melanoma cells and tissues.

RESULTS

PEDF was expressed in human melanocytes. The expression of PEDF protein diminished in the following orders healthy skin, pigmented nevus and human malignant melanoma (p < 0.001). Both the expression of PEDF mRNA and protein was much lower or almost absent in the malignant melanoma cell line A375 than that in human melanocytes (p < 0.001).

METHODS

The expression and distribution of PEDF in human healthy skin, pigmented nevus and malignant melanoma were studied. The expression of PEDF mRNA in human melanocytes and malignant melanoma cell line A375 was measured by reverse transcription polymerase chain reaction (RT-PCR) and PEDF protein was detected by immunohistochemical method and Western blotting analysis.

CONCLUSION

The lack of PEDF expression may contribute to the pathogenesis of malignant melanoma.

摘要

背景

色素上皮衍生因子（PEDF）最初是从人胎儿视网膜色素上皮细胞条件培养基中分离出来的，并且已在多种人胎儿和成人组织中检测到。最近的研究表明，PEDF活性对血管生成具有抑制作用。

目的

研究色素上皮衍生因子（PEDF）在人黑素细胞、恶性黑色素瘤细胞及组织中的表达与分布。

结果

PEDF在人黑素细胞中表达。PEDF蛋白表达在健康皮肤、色素痣和人恶性黑色素瘤中依次降低（p < 0.001）。恶性黑色素瘤细胞系A375中PEDF mRNA和蛋白的表达均远低于人黑素细胞或几乎缺失（p < 0.001）。

方法

研究PEDF在人健康皮肤、色素痣和恶性黑色素瘤中的表达与分布。采用逆转录聚合酶链反应（RT-PCR）检测人黑素细胞和恶性黑色素瘤细胞系A375中PEDF mRNA的表达，采用免疫组织化学方法和蛋白质印迹分析检测PEDF蛋白。

结论

PEDF表达缺失可能与恶性黑色素瘤的发病机制有关。