Division of Hematology and Oncology, Department of Pediatrics, Chang Gung Children's Hospital, Chang Gung University, Taoyuan, Taiwan.
Int J Hematol. 2010 May;91(4):670-2. doi: 10.1007/s12185-010-0537-5. Epub 2010 Mar 12.
This report exemplified a success of unrelated donor cord blood transplantation (CBT) in a 4-month-old boy with chronic granulomatous disease (CGD). Following Bu14/Cy200/ATG conditioning, the patient received an HLA 2-locus-mismatched cord blood unit, and the total number of infused nucleated cells was 11.52 x 10(7)/kg. Neutrophil engraftment was achieved on day +13, and a platelet count greater than 20 x 10(9)/L was achieved on day +50. The neutrophil oxidative burst was 100% normal with full donor lymphocyte reconstitution at 8 months post-transplant. This case highlights that unrelated donor CBT for CGD is potentially safe and feasible, even in early infancy, when an appropriately matched related or unrelated donor is unavailable.
本报告举例说明了一名 4 个月大的慢性肉芽肿病（CGD）男童进行无关供者脐血移植（CBT）的成功案例。在 Bu14/Cy200/ATG 预处理后，该患者接受了一个 HLA 2 位点不合的脐血单位，输注的有核细胞总数为 11.52 x 10(7)/kg。移植后第 13 天中性粒细胞植入，第 50 天血小板计数大于 20 x 10(9)/L。移植后 8 个月时，中性粒细胞氧化爆发完全正常，完全供者淋巴细胞重建。本案例强调了即使在早期婴儿期，当无法获得合适匹配的相关或无关供者时，无关供者 CBT 治疗 CGD 也是安全可行的。
