Department of Pediatrics, Changhua Christian Children's Hospital, Changhua, Taiwan, ROC; School of Medicine, Chung Shan Medical University, Taichung, Taiwan, ROC.
Department of Pediatrics, Changhua Christian Children's Hospital, Changhua, Taiwan, ROC.
Pediatr Neonatol. 2015 Oct;56(5):346-50. doi: 10.1016/j.pedneo.2013.04.001. Epub 2013 May 13.
A 19-month-old boy with chronic granulomatous disease (CGD) received umbilical cord blood transplantation (UCBT) from an unrelated donor after experiencing a life-threatening disseminated Bacillus Calmette-Guérin infection. After busulfan and cyclophosphamide conditioning, we performed a 5/6-matched UCBT. Engraftment and mixed chimerism was 100% in peripheral blood, and 100% of his neutrophils had normal oxidative burst activity on day 17. The patient is now 3 years old, free from infection, and growing well. To our knowledge, this is the second case of CGD treated with UCBT in Taiwan. His successful outcome illustrates that UCBT in a patient with CGD should be considered early if a human leukocyte antigen-matched donor is not available or the patient has just recovered from a severe infection.
一名 19 个月大的男孩患有慢性肉芽肿病（CGD），在经历了危及生命的卡介苗播散性感染后，他接受了来自无关供体的脐带血移植（UCBT）。在接受了白消安和环磷酰胺预处理后，我们进行了 5/6 配型的 UCBT。外周血中 100%发生了嵌合，并且他的中性粒细胞在第 17 天 100%具有正常的氧化爆发活性。该患者现在 3 岁，没有感染，生长良好。据我们所知，这是台湾用 UCBT 治疗 CGD 的第二例病例。他的成功结果表明，如果没有人类白细胞抗原匹配的供体，或者患者刚刚从严重感染中恢复过来，应考虑早期对 CGD 患者进行 UCBT。
