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Comparison of drug permeabilities and BCS classification: three lipid-component PAMPA system method versus Caco-2 monolayers.

作者信息

Teksin Zeynep S, Seo Paul R, Polli James E

机构信息

University of Maryland School of Pharmacy, Baltimore, Maryland 21201, USA.

出版信息

AAPS J. 2010 Jun;12(2):238-41. doi: 10.1208/s12248-010-9176-2. Epub 2010 Mar 12.

Abstract
摘要

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本文引用的文献

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Transport evaluation of salicylic acid and structurally related compounds across Caco-2 cell monolayers and artificial PAMPA membranes.
Eur J Pharm Biopharm. 2008 Oct;70(2):531-8. doi: 10.1016/j.ejpb.2008.05.017. Epub 2008 Jun 6.
4
Ion pair-mediated transport of metoprolol across a three lipid-component PAMPA system.
J Control Release. 2006 Nov;116(1):50-7. doi: 10.1016/j.jconrel.2006.08.020. Epub 2006 Sep 6.
5
Lipid composition effect on permeability across PAMPA.
Eur J Pharm Sci. 2006 Nov;29(3-4):259-68. doi: 10.1016/j.ejps.2006.04.012. Epub 2006 May 4.
6
7
Development and evaluation of an in vitro method for prediction of human drug absorption II. Demonstration of the method suitability.
Eur J Pharm Sci. 2006 Mar;27(4):354-62. doi: 10.1016/j.ejps.2005.11.005. Epub 2005 Dec 20.
9
Caco-2 permeability of weakly basic drugs predicted with the double-sink PAMPA pKa(flux) method.
Eur J Pharm Sci. 2005 Mar;24(4):333-49. doi: 10.1016/j.ejps.2004.11.011. Epub 2005 Jan 20.

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