Nishijima Hironobu, Kitahara Nobuo, Murata Mari, Egami Naoya
Department of Otolaryngology Showa General Hospital, Tokyo.
Nihon Jibiinkoka Gakkai Kaiho. 2010 Feb;113(2):62-6. doi: 10.3950/jibiinkoka.113.62.
Distant metastasis from differentiated thyroid carcinoma is rare and metastasis to the paranasal sinus is extremely rare. We report a case of differentiated papillary thyroid carcinoma (PTC) with metastases to the sphenoid sinus presenting with epistaxis. An 81-year-old undergoing partial lobectomy for differentiated PTC 9 years earlier presented with intermittent epistaxis. Imaging showed a mass filling the sphenoid sinus and extending to the intracranial cavity. Histopathological diagnosis using endoscopic biopsy indicated a metastatic PTC tumor. Compared to the primary site, the metastatic tumor was poorly differentiated thyroid carcinoma. Despite external beam radiation therapy, her general condition worsened and she was moved to a hospice.
分化型甲状腺癌的远处转移很少见,转移至鼻窦极为罕见。我们报告一例分化型乳头状甲状腺癌(PTC)转移至蝶窦并伴有鼻出血的病例。一名81岁女性9年前因分化型PTC接受了部分甲状腺叶切除术,现出现间歇性鼻出血。影像学检查显示蝶窦内有一肿块并延伸至颅内腔。经内镜活检进行的组织病理学诊断显示为转移性PTC肿瘤。与原发部位相比,转移瘤为低分化甲状腺癌。尽管进行了外照射放疗,但其总体状况仍恶化,随后被转至临终关怀病房。