Department of Obstetrics and Gynecology, Washington University School of Medicine, St Louis, MO 63110, USA.
Mitochondrion. 2010 Aug;10(5):403-10. doi: 10.1016/j.mito.2010.03.002. Epub 2010 Mar 11.
Maternal diabetes has been demonstrated to adversely affect preimplantation embryo development and pregnancy outcomes. Emerging evidence has implicated that these effects are associated with compromised oocyte competence. Several developmental defects during oocyte maturation in diabetic mice have been reported over past decades. Most recently, we further identified the structural, spatial and metabolic dysfunction of mitochondria in oocytes from diabetic mice, suggesting the impaired oocyte quality. These defects in the oocyte may be maternally transmitted to the embryo and then manifested later as developmental abnormalities in preimplantation embryo, congenital malformations, and even metabolic disease in the offspring. In this paper, we briefly review the effects of maternal diabetes on oocyte quality, with a particular emphasis on the mitochondrial dysfunction. The possible connection between dysfunctional oocyte mitochondria and reproductive failure of diabetic females, and the mechanism(s) by which maternal diabetes exerts its effects on the oocyte are also discussed.
母体糖尿病已被证明会对胚胎着床前胚胎发育和妊娠结局产生不利影响。新出现的证据表明，这些影响与卵母细胞功能受损有关。过去几十年的研究表明，糖尿病小鼠卵母细胞成熟过程中存在多种发育缺陷。最近，我们进一步发现糖尿病小鼠卵母细胞中线粒体的结构、空间和代谢功能障碍，提示卵母细胞质量受损。卵母细胞中的这些缺陷可能会从母体传递到胚胎，然后在胚胎着床前表现为发育异常、先天性畸形，甚至后代的代谢疾病。本文简要综述了母体糖尿病对卵母细胞质量的影响，特别强调了线粒体功能障碍。还讨论了卵母细胞线粒体功能障碍与糖尿病女性生殖失败之间的可能联系，以及母体糖尿病对卵母细胞发挥作用的机制。
