[一名威尔逊氏病患者的肝脏恶性肿瘤]

[Liver malignancy in a patient with Wilson's disease].

作者信息

Pioche M, Marion-Audibert A-M, Thevenet-d'Yvoire C, Rode A, Bancel B, Mabrut J-Y, Pere-Verge D, Souquet J-C

机构信息

Service d'hépatogastroentérologie, hôpital de la Croix-Rousse, 103, grande rue de la Croix-Rousse, 69317 Lyon cedex 04, France.

出版信息

Rev Med Interne. 2010 Jun;31(6):e7-9. doi: 10.1016/j.revmed.2009.05.009. Epub 2010 Mar 12.

DOI:10.1016/j.revmed.2009.05.009

PMID:20227147

Abstract

Hepatocellular carcinoma and other tumours of the liver are extremely rare in Wilson's disease. We report a patient who presented with a cholangiocarcinoma associated with Wilson's disease. The literature review underlines that patients with Wilson's disease should be considered at risk of hepatocellular carcinoma, cholangiocarcinoma and undifferentiated carcinoma in the liver. Risk factors seem to be long disease duration and probably a poor observance to therapy. A liver imaging should be included in the follow-up of patients with Wilson's disease.

摘要

肝细胞癌和其他肝脏肿瘤在威尔逊病中极为罕见。我们报告了一名患有与威尔逊病相关的胆管癌的患者。文献综述强调，威尔逊病患者应被视为有患肝细胞癌、胆管癌和肝脏未分化癌的风险。风险因素似乎是病程长以及可能对治疗的依从性差。威尔逊病患者的随访应包括肝脏影像学检查。