Department of Otorhinolaryngology, University Hospital, Friedrich Schiller University Jena, Jena, Germany.
Oral Oncol. 2010 Apr;46(4):e5-9. doi: 10.1016/j.oraloncology.2010.01.005.
Head and neck in situ carcinoma is seldom diagnosed. Our knowledge about in situ cancer is limited. This study describes the epidemiology and prognosis of head and neck in situ cancer in Thuringia, Germany. We analyzed the cancer data of the Thuringian cancer registry database from 1996 to 2005. The database contained 3821 patients with primary head and neck cancer. Thirty-four patients (0.88%) had an in situ carcinoma. They were evaluated for patient's characteristics, tumor stage, incidence, treatment and trends in overall survival (OS) and recurrence-free survival (RFS). During 1996-2005, the average annual incidence of head and neck in situ carcinoma was 0.14 per 100,000 persons. Half of the cases were localized in the larynx. The patients were treated by local excision. Six patients (18%) developed a local recurrence. Only one recurrent tumor was diagnosed in early stage (rT1), but the other five tumors in advanced stage (rT3/rT4). The median time to recurrence was 27.43 months. For all 34 patients with in situ carcinoma, the 5-year OS was 84% and the 5-year RFS 60.4%. OS was better for laryngeal in situ cancer than for oral cavity or pharyngeal in situ cancer (p=0.031). The surveillance of patients with head and neck in situ carcinoma after treatment should be performed like in patients with invasive cancer, because nearly one fifth of patients developed a recurrence, predominantly in advanced stage.
头颈部原位癌很少被诊断。我们对头颈部原位癌的认识有限。本研究描述了德国图林根州头颈部原位癌的流行病学和预后。我们分析了 1996 年至 2005 年图林根癌症登记数据库的癌症数据。该数据库包含 3821 例原发性头颈部癌症患者。34 例（0.88%）患者患有原位癌。评估了患者特征、肿瘤分期、发病率、治疗以及总生存率（OS）和无复发生存率（RFS）的趋势。1996 年至 2005 年期间，头颈部原位癌的平均年发病率为每 10 万人中有 0.14 例。半数病例位于喉。患者接受局部切除术治疗。6 例（18%）发生局部复发。仅 1 例复发性肿瘤诊断为早期（rT1），但其余 5 例肿瘤为晚期（rT3/rT4）。复发的中位时间为 27.43 个月。所有 34 例原位癌患者的 5 年 OS 为 84%，5 年 RFS 为 60.4%。喉原位癌的 OS 优于口腔或咽原位癌（p=0.031）。治疗后对头颈部原位癌患者的监测应与侵袭性癌症患者一样进行，因为近五分之一的患者出现复发，主要是晚期复发。
