Blanchard E, Wierzbicka-Hainaut E, Thellier S, Dupeyron F, Guillet G
Service de dermatologie, hôpital la Miletrie, CHU de Poitiers, 86021 Poitiers cedex, France.
Ann Dermatol Venereol. 2010 Mar;137(3):216-9. doi: 10.1016/j.annder.2010.01.008. Epub 2010 Feb 18.
Basal cell carcinoma is the most common carcinoma of the skin and is usually found on the head and neck. We report an unusual case of basal cell carcinoma presenting as a chronic leg ulcer, with underlying bone involvement.
A 70-year-old woman presented with a 15-year history of leg ulcer refractory to treatment. Because of the exuberant granulation tissue on the base and the indurated edges of this circumferential leg ulcer, several biopsies were taken from the edge and the base of the ulcer. Histological examination revealed infiltrative basal cell carcinoma. Treatment consisted of surgical excision of 80% of the primary lesion and coverage with a split-thickness skin graft. Examination of the surgical piece revealed invasion of bone by the carcinoma. The remainder of the lesion not accessible to surgery was irradiated.
There is a need for awareness among all doctors of the clinical signs evocative of malignant transformation of a leg ulcer so that a skin biopsy may be performed for suspicious ulcers. Our case is distinguished by the underlying invasion of bone by basal cell carcinoma, as attested by imaging and histology.
基底细胞癌是最常见的皮肤癌,通常发生于头颈部。我们报告一例罕见的基底细胞癌病例,表现为慢性腿部溃疡,并伴有潜在的骨质受累。
一名70岁女性,有15年腿部溃疡病史,治疗效果不佳。由于该环形腿部溃疡底部有大量肉芽组织且边缘硬结,遂从溃疡边缘和底部取了多次活检。组织学检查显示为浸润性基底细胞癌。治疗方法包括手术切除80%的原发灶,并进行中厚皮片移植覆盖。对手术切除标本的检查显示癌组织侵犯了骨质。手术无法触及的其余病变部位接受了放射治疗。
所有医生都需要了解提示腿部溃疡发生恶性转化的临床体征,以便对可疑溃疡进行皮肤活检。我们的病例特点是基底细胞癌侵犯了骨质,影像学和组织学检查均证实了这一点。