Al Majed Badr M, Koonce Stephanie L, Eck Dustin L, Murray Peter, Perdikis Galen
Department of Plastic Surgery, Mayo Clinic, Jacksonville, Fla.
Eplasty. 2013 Nov 13;13:e59. eCollection 2013.
Basal cell carcinoma is the most prevalent form of cancer worldwide, usually arising in the head and neck region, which is cured by surgical excision and rarely invades or metastasizes. Many reports exist of bony invasion in the head and neck but very rarely into long bones.
We report an unusual case of basal cell carcinoma that despite surgical excision, directly invaded the left humerus. This article also includes a literature review with possible explanations for the occasionally aggressive behavior of basal cell carcinoma.
This 68-year-old patient underwent wide resection of the affected left upper arm skin, tissue, and diaphyseal segment with clear margins. The defect was reconstructed with a vascularized free fibula bone graft, pedicled latissimus muscle flap, and split-thickness skin graft.
Long bone invasion by BCC is extremely rare and not well reported. There are more biologic explanations for overtly aggressive behavior that BCC may exhibit such as in this case.
基底细胞癌是全球最常见的癌症形式，通常发生于头颈部区域，可通过手术切除治愈，极少发生侵袭或转移。头颈部骨侵袭的报道众多，但累及长骨的情况极为罕见。
我们报告了一例罕见的基底细胞癌病例，尽管进行了手术切除，但该肿瘤仍直接侵犯了左肱骨。本文还包括文献综述，探讨了基底细胞癌偶尔出现侵袭性行为的可能原因。
这位68岁的患者接受了患侧左上臂皮肤、组织及骨干节段的广泛切除，切缘清晰。缺损采用带血管游离腓骨骨移植、背阔肌肌皮瓣及中厚皮片移植进行修复。
基底细胞癌侵犯长骨极为罕见，相关报道较少。对于基底细胞癌可能表现出的如本病例中明显的侵袭性行为，有更多生物学方面的解释。
