Centre for Biopharmaceutics and Pharmacokinetics, University College of Pharmaceutical Sciences, Kakatiya University, Warangal-506009 (A.P.), India.
Acta Pharm. 2010 Mar;60(1):89-97. doi: 10.2478/v10007-010-0001-3.
A biphasic gastroretentive drug delivery system of fenoverine was developed to maintain constant plasma concentration. The delivery system consisted of a loading-dose tablet and a floating multiple matrix tablet prepared by the direct compression process. The drug release from biphasic GRDDS in 0.1 mol L(-1) HCl and SGF (enzyme free) was sustained over 12 h with buoyant properties. Stability studies showed no significant change in dissolution profiles (f2 value > 50). Based on the release kinetics, it can be concluded that the floating multiple matrix tablet containing HPMC was a particularly suitable gastroretentive drug delivery system with a zero-order release profile.
开发了一种芬维 A 的双相胃滞留药物传递系统，以维持稳定的血浆浓度。该传递系统由负荷剂量片剂和通过直接压缩工艺制备的漂浮型多基质片剂组成。双相 GRDDS 在 0.1 mol/L HCl 和 SGF（无酶）中的药物释放可持续 12 小时以上，并具有漂浮性能。稳定性研究表明，溶出曲线无明显变化（f2 值>50）。根据释放动力学，可以得出结论，含有 HPMC 的漂浮型多基质片剂是一种特别适合的胃滞留药物传递系统，具有零级释放特征。
