Sharad Pawar College of Pharmacy, Wanadongri, Nagpur-441110 (M.S.), India.
Acta Pharm. 2010 Mar;60(1):111-7. doi: 10.2478/v10007-010-0005-z.
Biodegradable implants of ciprofloxacin hydrochloride for post operative site delivery were prepared using glyceryl monostearate and different concentrations of polyethylene glycol (PEG 6000), glycerol and Tween 80 as erosion enhancers by compression and molding technique. Formulations were subjected to in vitro drug release by the USP dissolution method, while promising formulations were subjected to in vitro drug release by the agar gel method and also to stability studies. It was observed that glyceryl monostearate formed hydrophobic matrix and delayed the drug delivery. Antibiotic release profile was controlled by using different combinations of erosion enhancers. The formulation prepared by the compression method showed more delayed release compared to formulations prepared by the molding method.
采用甘油单硬脂酸酯和不同浓度的聚乙二醇（PEG6000）、甘油和吐温 80 作为侵蚀增强剂，通过压缩和成型技术制备盐酸环丙沙星的可生物降解植入物，用于术后部位给药。通过 USP 溶解法对制剂进行体外药物释放，同时对有前途的制剂进行琼脂凝胶法体外药物释放和稳定性研究。结果表明，甘油单硬脂酸酯形成疏水性基质并延迟药物释放。通过使用不同组合的侵蚀增强剂来控制抗生素释放曲线。通过压缩法制备的制剂与通过成型法制备的制剂相比，显示出更延迟的释放。
