Division of Thoracic and Hyperbaric Surgery, Medical University of Graz, Graz, Austria.
J Antimicrob Chemother. 2010 May;65(5):995-8. doi: 10.1093/jac/dkq070. Epub 2010 Mar 12.
The present investigation explored the ability of fosfomycin to penetrate lung tissue of septic patients by utilizing the microdialysis technique.
After microdialysis probe insertion into healthy and infected lung tissue, a single intravenous dose of 4 g of fosfomycin was administered.
The mean C(max), T(max), AUC(0-4) and AUC(0-infinity) for healthy lung were 131.6 +/- 110.6 mg/L, 1.1 +/- 0.4 h, 242.4 +/- 101.6 mgxh/L and 367.6 +/- 111.9 mgxh/L, respectively. The corresponding values for infected lung were 107.5 +/- 60.2 mg/L, 1.4 +/- 0.5 h, 203.5 +/- 118.4 mgxh/L and 315.1 +/- 151.2 mgxh/L. The half-life of fosfomycin ranged from 2.2 to 2.7 h between compartments. The magnitude of lung tissue penetration, as determined by the ratios of the AUC(0-infinity) for lung to the AUC(0-infinity) for plasma, was 0.63 +/- 0.31 and 0.53 +/- 0.31 for healthy and infected lung, respectively.
We conclude that fosfomycin achieves antimicrobially effective concentrations in infected lung tissue.
本研究利用微透析技术探讨磷霉素穿透脓毒症患者肺部组织的能力。
在健康和感染的肺组织中插入微透析探针后，给予单剂量 4 g 磷霉素静脉注射。
健康肺组织的 C(max)、T(max)、AUC(0-4)和 AUC(0-∞)的平均值分别为 131.6 ± 110.6 mg/L、1.1 ± 0.4 h、242.4 ± 101.6 mgxh/L 和 367.6 ± 111.9 mgxh/L。感染肺组织的相应值分别为 107.5 ± 60.2 mg/L、1.4 ± 0.5 h、203.5 ± 118.4 mgxh/L 和 315.1 ± 151.2 mgxh/L。磷霉素的半衰期在不同隔室之间为 2.2 至 2.7 h。通过 AUC(0-∞)比肺组织与血浆 AUC(0-∞)的比值来确定肺组织穿透程度，健康和感染肺组织的比值分别为 0.63 ± 0.31 和 0.53 ± 0.31。
我们得出结论，磷霉素在感染的肺组织中达到了抗菌有效的浓度。
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