Osoegawa Atsushi, Nosaki Kaname, Miyamoto Hitoshi, Kometani Takuro, Hirai Fumihiko, Ondo Kaoru, Seto Takashi, Sugio Kenji, Choi Young Lim, Soda Manabu, Mano Hiroyuki, Ichinose Yukito
Department of Thoracic Oncology, National Kyushu Cancer Center, Fukuoka.
Intern Med. 2010;49(6):603-6. doi: 10.2169/internalmedicine.49.3126. Epub 2010 Mar 15.
Genetic alterations of echinoderm microtubule-associated protein-like 4 (EML4)-anaplastic lymphoma kinase (ALK) inversion were recently found in lung cancer. A 39-year-old woman with multiple brain metastases and bulky mediastinal lymph node metastases was admitted. Biopsy from her supraclavicular lymph nodes was performed to differentiate the diagnosis between lymphoma and lung cancer. Pathologically, the lymph nodes had a feature of adenocarcinoma. On the other hand, the commercially available chromosomal fluorescent in situ hybridization (FISH) analysis showed split signals of ALK, which was confirmed to be the EML4-ALK inversion. The commercial-based ALK FISH is useful for screening pulmonary ALKoma.
近期在肺癌中发现了棘皮动物微管相关蛋白样 4（EML4）-间变性淋巴瘤激酶（ALK）倒位的基因改变。一名 39 岁患有多处脑转移和巨大纵隔淋巴结转移的女性入院。对其锁骨上淋巴结进行活检以鉴别淋巴瘤和肺癌。病理检查显示淋巴结具有腺癌特征。另一方面，市售的染色体荧光原位杂交（FISH）分析显示 ALK 出现分离信号，经证实为 EML4-ALK 倒位。基于商业检测的 ALK FISH 对筛查肺 ALK 阳性肿瘤有用。
