Wu Shih-Yun, Chen Yen-Ting, Chen Chi-Wei, Chi Lin-Yang, Hsu Nai-Ying, Hung Shan-Ling, Ling Li-Jane
Department of Periodontics, Taipei Veterans General Hospital, Taiwan.
Int J Periodontics Restorative Dent. 2010 Apr;30(2):173-9.
This prospective, randomized, controlled clinical trial compared the clinical outcomes for a polylactic acid barrier versus a collagen membrane in conjunction with guided tissue regeneration (GTR). Thirty patients with chronic periodontitis and at least one intrabony defect of a minimum 4 mm were enrolled. Following full-mouth scaling, GTR using a collagen membrane or a polylactic acid barrier was performed at one site in each patient. At 1 week before and 6 months after surgery, probing pocket depth (PPD), clinical attachment level (CAL), marginal tissue recession, and bone fill were assessed. A significant reduction in PPD (2.50 +/- 1.35 mm for the polylactic acid barrier and 2.60 +/- 1.08 mm for the collagen membrane) was obtained, in addition to gains in CAL (2.40 +/- 1.17 mm for the polylactic acid barrier and 2.60 +/- 1.26 mm for the collagen membrane) and bone fill (0.33 +/- 1.89 mm for polylactic acid barrier and 2.57 +/- 1.64 mm for collagen membrane), for each group compared to baseline. Significantly, the results from 6 months after surgery showed that there was greater bone fill when the collagen membrane was used compared to the polylactic acid barrier.
这项前瞻性、随机、对照临床试验比较了聚乳酸屏障与胶原膜联合引导组织再生（GTR）的临床效果。纳入了30例患有慢性牙周炎且至少有一处至少4毫米深骨内缺损的患者。在进行全口洁治后，对每位患者的一个部位进行使用胶原膜或聚乳酸屏障的GTR治疗。在手术前1周和术后6个月，评估探诊深度（PPD）、临床附着水平（CAL）、边缘组织退缩和骨填充情况。与基线相比，每组的PPD均显著降低（聚乳酸屏障组为2.50±1.35毫米，胶原膜组为2.60±1.08毫米），同时CAL增加（聚乳酸屏障组为2.40±1.17毫米，胶原膜组为2.60±1.26毫米），骨填充增加（聚乳酸屏障组为0.33±1.89毫米，胶原膜组为2.57±1.64毫米）。值得注意的是，术后6个月的结果显示，与聚乳酸屏障相比，使用胶原膜时骨填充更多。
