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Is type 2 diabetes an amyloidosis and does it really matter (to patients)?

作者信息

Cooper G J S, Aitken J F, Zhang S

机构信息

School of Biological Sciences, and Maurice Wilkins Centre of Excellence for Molecular Biodiscovery, Faculty of Science, University of Auckland, Auckland, New Zealand.

出版信息

Diabetologia. 2010 Jun;53(6):1011-6. doi: 10.1007/s00125-010-1715-y. Epub 2010 Mar 13.

DOI:10.1007/s00125-010-1715-y
PMID:20229094
Abstract
摘要

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Is type 2 diabetes an amyloidosis and does it really matter (to patients)?2型糖尿病是一种淀粉样变性病吗？这真的（对患者）重要吗？
Diabetologia. 2010 Jun;53(6):1011-6. doi: 10.1007/s00125-010-1715-y. Epub 2010 Mar 13.
2
A feline model of experimentally induced islet amyloidosis.实验性诱导胰岛淀粉样变性的猫模型。
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3
Islet amyloidosis and beta-cell neogenesis in chronic calcifying pancreatitis with non-insulin-dependent diabetes mellitus.伴有非胰岛素依赖型糖尿病的慢性钙化性胰腺炎中的胰岛淀粉样变和β细胞新生
Pancreas. 2009 Apr;38(3):342-4. doi: 10.1097/MPA.0b013e31817fe025.
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Diabetes mellitus and islet amyloidosis in cynomolgus monkeys.食蟹猴的糖尿病和胰岛淀粉样变性
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[Amylin and amyloidosis of the pancreatic islets and their significance in the etiology and pathogenesis of diabetes mellitus type 2].[胰岛淀粉样多肽与胰岛淀粉样变性及其在2型糖尿病病因学和发病机制中的意义]
Ter Arkh. 1993;65(10):14-7.
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Diabetes mellitus in cystic fibrosis is characterized by islet amyloidosis.囊性纤维化中的糖尿病以胰岛淀粉样变性为特征。
J Clin Endocrinol Metab. 1996 Mar;81(3):1267-72. doi: 10.1210/jcem.81.3.8772610.
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beta-cell failure in diabetes and preservation by clinical treatment.糖尿病中的β细胞功能衰竭及临床治疗的保护作用。
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Beta-cell regeneration in human pancreas: the lessons of pancreatic pathology.人胰腺中的β细胞再生：胰腺病理学的启示。
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Amylin: emergent therapeutic opportunities in overweight, obesity and diabetes mellitus.胰淀素：超重、肥胖及糖尿病中的新兴治疗机遇
Nat Rev Endocrinol. 2025 May 13. doi: 10.1038/s41574-025-01125-9.
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Ameliorating amyloid aggregation through osmolytes as a probable therapeutic molecule against Alzheimer's disease and type 2 diabetes.通过渗透剂改善淀粉样蛋白聚集，作为一种可能针对阿尔茨海默病和2型糖尿病的治疗分子。
RSC Adv. 2020 Mar 25;10(21):12166-12182. doi: 10.1039/d0ra00429d. eCollection 2020 Mar 24.
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Altered metabolic gene expression in the brain of a triprolyl-human amylin transgenic mouse model of type 2 diabetes.

本文引用的文献

1
Toxic oligomers and islet beta cell death: guilty by association or convicted by circumstantial evidence?毒性寡聚物与胰岛β细胞死亡：关联定罪还是旁证定罪？
Diabetologia. 2010 Jun;53(6):1046-56. doi: 10.1007/s00125-010-1671-6. Epub 2010 Feb 25.
2
THE RELATION OE DIABETES MELLITUS TO LESIONS OF THE PANCREAS. HYALINE DEGENERATION OF THE ISLANDS OE LANGERHANS.糖尿病与胰腺病变的关系。朗格汉斯岛的透明变性。
J Exp Med. 1901 Mar 25;5(5):527-40. doi: 10.1084/jem.5.5.527.
3
Tetracycline treatment retards the onset and slows the progression of diabetes in human amylin/islet amyloid polypeptide transgenic mice.
2 型糖尿病三脯氨酰人胰岛淀粉样多肽转基因小鼠模型大脑代谢基因表达的改变。
Sci Rep. 2019 Oct 10;9(1):14588. doi: 10.1038/s41598-019-51088-x.
4
The triphenylmethane dye brilliant blue G is only moderately effective at inhibiting amyloid formation by human amylin or at disaggregating amylin amyloid fibrils, but interferes with amyloid assays; Implications for inhibitor design.三苯甲烷染料亮蓝 G 仅在一定程度上有效抑制人胰岛淀粉样肽的形成或使胰岛淀粉样肽纤维解聚，但会干扰淀粉样蛋白检测；对抑制剂设计的影响。
PLoS One. 2019 Aug 12;14(8):e0219130. doi: 10.1371/journal.pone.0219130. eCollection 2019.
5
The receptor for advanced glycation endproducts is a mediator of toxicity by IAPP and other proteotoxic aggregates: Establishing and exploiting common ground for novel amyloidosis therapies.晚期糖基化终产物受体是 IAPP 和其他蛋白毒性聚集物毒性的介质：为新型淀粉样变性疗法建立和利用共同基础。
Protein Sci. 2018 Jul;27(7):1166-1180. doi: 10.1002/pro.3425.
6
Islet Amyloid Polypeptide Membrane Interactions: Effects of Membrane Composition.胰岛淀粉样多肽与膜的相互作用：膜组成的影响。
Biochemistry. 2017 Jan 17;56(2):376-390. doi: 10.1021/acs.biochem.6b01016. Epub 2017 Jan 5.
7
Time-resolved studies define the nature of toxic IAPP intermediates, providing insight for anti-amyloidosis therapeutics.时间分辨研究确定了有毒胰岛淀粉样多肽中间体的性质，为抗淀粉样变性治疗提供了见解。
Elife. 2016 May 23;5:e12977. doi: 10.7554/eLife.12977.
8
Islet Amyloid Polypeptide: Structure, Function, and Pathophysiology.胰岛淀粉样多肽：结构、功能与病理生理学
J Diabetes Res. 2016;2016:2798269. doi: 10.1155/2016/2798269. Epub 2015 Nov 15.
9
Defining the molecular basis of amyloid inhibitors: human islet amyloid polypeptide-insulin interactions.确定淀粉样蛋白抑制剂的分子基础：人胰岛淀粉样多肽与胰岛素的相互作用。
J Am Chem Soc. 2014 Sep 17;136(37):12912-9. doi: 10.1021/ja504031d. Epub 2014 Sep 4.
10
Structural similarities and differences between amyloidogenic and non-amyloidogenic islet amyloid polypeptide (IAPP) sequences and implications for the dual physiological and pathological activities of these peptides.淀粉样肽（IAPP）序列的淀粉样形成和非淀粉样形成之间的结构相似性和差异，以及这些肽的双重生理和病理活性的影响。
PLoS Comput Biol. 2013;9(8):e1003211. doi: 10.1371/journal.pcbi.1003211. Epub 2013 Aug 29.
四环素治疗可延缓人类胰岛淀粉样多肽转基因小鼠糖尿病的发病并减缓其进展。
Diabetes. 2010 Jan;59(1):161-71. doi: 10.2337/db09-0548. Epub 2009 Sep 30.
4
Distinct structures of scrapie prion protein (PrPSc)-seeded versus spontaneous recombinant prion protein fibrils revealed by hydrogen/deuterium exchange.通过氢/氘交换揭示的羊瘙痒病朊病毒蛋白（PrPSc）种子化与自发重组朊病毒蛋白原纤维的不同结构
J Biol Chem. 2009 Sep 4;284(36):24233-41. doi: 10.1074/jbc.M109.036558. Epub 2009 Jul 13.
5
Coexpression of the type 2 diabetes susceptibility gene variants KCNJ11 E23K and ABCC8 S1369A alter the ATP and sulfonylurea sensitivities of the ATP-sensitive K(+) channel.2型糖尿病易感基因变异体KCNJ11 E23K和ABCC8 S1369A的共表达改变了ATP敏感性钾通道的ATP和磺脲类药物敏感性。
Diabetes. 2009 Oct;58(10):2419-24. doi: 10.2337/db09-0143. Epub 2009 Jul 8.
6
A variant in the KCNQ1 gene predicts future type 2 diabetes and mediates impaired insulin secretion.KCNQ1基因中的一个变体可预测未来患2型糖尿病的风险，并介导胰岛素分泌受损。
Diabetes. 2009 Oct;58(10):2409-13. doi: 10.2337/db09-0246. Epub 2009 Jul 7.
7
Amyloid deposits: protection against toxic protein species?淀粉样沉积物：对有毒蛋白质种类的保护作用？
Cell Cycle. 2009 Jun 1;8(11):1668-74. doi: 10.4161/cc.8.11.8503. Epub 2009 Jun 20.
8
Protein misfolding inside cells: the case of huntingtin and Huntington's disease.细胞内蛋白质错误折叠：亨廷顿蛋白与亨廷顿舞蹈症的案例
IUBMB Life. 2008 Nov;60(11):724-8. doi: 10.1002/iub.111.
9
Spontaneous diabetes in hemizygous human amylin transgenic mice that developed neither islet amyloid nor peripheral insulin resistance.半合子人胰淀素转基因小鼠出现自发性糖尿病，既未形成胰岛淀粉样变，也未出现外周胰岛素抵抗。
Diabetes. 2008 Oct;57(10):2737-44. doi: 10.2337/db06-1755. Epub 2008 Jul 15.
10
A drastic reduction in the life span of cystatin C L68Q carriers due to life-style changes during the last two centuries.由于过去两个世纪生活方式的改变，胱抑素C L68Q携带者的寿命大幅缩短。
PLoS Genet. 2008 Jun 20;4(6):e1000099. doi: 10.1371/journal.pgen.1000099.