National Institute of Nutrition, Hanoi, Vietnam.
J Agric Food Chem. 2010 Apr 14;58(7):4162-8. doi: 10.1021/jf904304w.
The aim of the present study was to examine whether an aqueous extract of Cleistocalyx operculatus flower buds (COB) had protective and anticataract effects on beta-cells in experimental streptozotocin (STZ)-induced diabetes in rats. After 9 weeks of COB supplementation (500 mg/kg bw), the COB group had a significantly more stable insulin level as compared with the control diabetic group. Increased staining of insulin and preservation of islet cells were apparent in the COB-treated diabetic rats, whereas islet cell degeneration and weak insulin immunohistochemical staining were observed in the control diabetic rats. In addition, COB significantly delayed diabetic cataract formation and caused significant reductions in the glucose, sorbitol, and fructose levels in diabetic rat lenses. Furthermore, as compared to the control diabetic group, the COB group also showed antihyperglycemic effects (reductions in plasma glucose and HbA1c levels).
本研究旨在探讨五桠果花水提物（COB）对实验性链脲佐菌素（STZ）诱导的糖尿病大鼠β细胞是否具有保护和抗白内障作用。经过 9 周的 COB 补充（500mg/kg bw），COB 组的胰岛素水平明显比对照组糖尿病大鼠更稳定。COB 治疗的糖尿病大鼠的胰岛素染色增加，胰岛细胞得到保存，而对照组糖尿病大鼠则观察到胰岛细胞变性和弱的胰岛素免疫组织化学染色。此外，COB 显著延缓了糖尿病性白内障的形成，并导致糖尿病大鼠晶状体中葡萄糖、山梨醇和果糖水平的显著降低。此外，与对照组糖尿病组相比，COB 组还表现出降血糖作用（降低血浆葡萄糖和 HbA1c 水平）。
