Kaya Dayimi, Barutcu Irfan, Esen Ali Metin, Celik Atac, Onrat Ersel
Dr.Suat Seren Chest Disease and Surgery Education and Research Hospital, Department of Cardiology, Izmir, Turkey.
Pacing Clin Electrophysiol. 2010 Aug;33(8):929-33. doi: 10.1111/j.1540-8159.2010.02727.x. Epub 2010 Mar 8.
Moxonidine, an imidazoline I1 receptor agonist, is a centrally acting antihypertensive agent having sympatholytic effect. However, there are only limited data regarding the effects of this drug on autonomic cardiac functions.
In this study we investigated the acute effects of moxonidine on cardiac autonomic modulation by heart rate variability (HRV) analysis. The effects of oral 0.4-mg moxonidine were studied on 11 healthy male volunteers in a randomized, double-blind, placebo controlled, and crossover study. After 15 minutes rest, time and frequency domain parameters of HRV were calculated from 5-minute continue electrocardiography recordings in supine position, during controlled respiration (15 breath/min) and during handgrip exercise before and 1 hour after taking placebo or moxonidine. Baseline parameters before taking placebo and moxonidine were similar (P > 0.05). Moxonidine, but not placebo, caused an increase in heart failure (HF) (119 +/- 21 vs 156 +/- 23, P = 0.029) and HFnu (39 +/- 4 vs 47 +/- 4, P = 0.033) and decrease in LFnu (61 +/- 4 vs 53 +/- 4, P = 0.033) and LF/HF ratio (1.96 +/- 0.36 vs 1.12 +/- 0.35, P = 0.010) in supine position compared with baseline parameters. However, there was no difference in other time or frequency domain parameters during controlled breathing and handgrip exercise either with moxonidine or placebo administration (P > 0.05). Single dose of moxonidine administration increases cardiovagal tone but parasympathetic and sympathetic autonomic maneuvers attenuated its short term effects on HRV in healthy male subjects.
莫索尼定是一种咪唑啉I1受体激动剂，是一种具有交感神经抑制作用的中枢性抗高血压药物。然而，关于该药物对自主心脏功能影响的数据有限。
在本研究中，我们通过心率变异性（HRV）分析研究了莫索尼定对心脏自主调节的急性影响。在一项随机、双盲、安慰剂对照和交叉研究中，对11名健康男性志愿者研究了口服0.4mg莫索尼定的效果。休息15分钟后，在服用安慰剂或莫索尼定前及服药后1小时，于仰卧位、控制呼吸（15次/分钟）和握力运动期间，通过5分钟连续心电图记录计算HRV的时域和频域参数。服用安慰剂和莫索尼定前的基线参数相似（P>0.05）。与基线参数相比，莫索尼定而非安慰剂导致仰卧位时心力衰竭（HF）增加（119±21对156±23，P=0.029）和HFnu增加（39±4对47±4，P=0.033），以及LFnu降低（61±4对53±4，P=0.033）和LF/HF比值降低（1.96±0.36对1.12±0.35，P=0.010）。然而，在控制呼吸和握力运动期间，服用莫索尼定或安慰剂时，其他时域或频域参数均无差异（P>0.05）。单剂量服用莫索尼定可增加心脏迷走神经张力，但副交感神经和交感神经自主操作可减弱其对健康男性受试者HRV的短期影响。
