非裔美国人中KIR3DL1和KIR3DS1等位基因的分布情况与非洲人群中的相似。

The profile of KIR3DL1 and KIR3DS1 alleles in an African American population resembles that found in African populations.

作者信息

Jiang B, Hou L, Chen M, Ng J, Hurley C K

机构信息

Departments of Pediatrics and Oncology, CW Bill Young Marrow Donor Recruitment and Research Program, Georgetown University Medical Center, Washington, D.C. 20057, USA.

出版信息

Tissue Antigens. 2010 Jul;76(1):64-6. doi: 10.1111/j.1399-0039.2010.01468.x. Epub 2010 Mar 10.

DOI:10.1111/j.1399-0039.2010.01468.x

PMID:20230527

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3485638/

Abstract

KIR3DL1 and KIR3DS1 allele frequencies were determined by DNA sequencing of the complete coding regions from 100 random unrelated African Americans. Alleles 3DL101501 (29 individuals) and 3DL101502 (23 individuals) were most frequently observed in addition to 21 other known alleles and 7 new alleles: KIR3DL1*01503, *03102, *064, *065, *066, 067, and 068. Two of the new alleles (KIR3DL1064, 065) created additional variants of the chimeric KIR3DL1/KIR3DL2 gene. KIR3DS101301 (94% of the gene positive individuals) and KIR3DS1049N (11%) were identified in the 18 individuals carrying this gene. Three individuals appeared to carry a killer cell immunoglobulin-like receptor haplotype with KIR3DL1/S1 duplication. The profile of alleles resembles that found in African populations but also shows signs of admixture.

摘要

通过对100名随机选取的非亲属非裔美国人的完整编码区进行DNA测序，确定了KIR3DL1和KIR3DS1等位基因频率。除了21个其他已知等位基因和7个新等位基因（KIR3DL1*01503、03102、064、065、066、067和068）外，最常观察到的等位基因是3DL101501（29人）和3DL101502（23人）。其中两个新等位基因（KIR3DL1064、065）产生了嵌合KIR3DL1/KIR3DL2基因的额外变体。在携带该基因的18名个体中鉴定出KIR3DS101301（94%的基因阳性个体）和KIR3DS1049N（11%）。三名个体似乎携带具有KIR3DL1/S1重复的杀伤细胞免疫球蛋白样受体单倍型。等位基因谱与非洲人群中的相似，但也显示出混合的迹象。