犬皮肤肥大细胞瘤中前列腺素 E2 和血管内皮生长因子的免疫组织化学评估。

Immunohistochemical evaluation of prostaglandin E2 and vascular endothelial growth factor in canine cutaneous mast cell tumours.

机构信息

School of Veterinary Medicine and Animal Science, UNESP, Botucatu, São Paulo, Brazil.

出版信息

Vet Comp Oncol. 2010 Mar;8(1):23-7. doi: 10.1111/j.1476-5829.2009.00202.x.

DOI:10.1111/j.1476-5829.2009.00202.x

PMID:20230578

Abstract

Vascular endothelial growth factor (VEGF) and prostaglandin E2 (PGE-2) appear to play a critical role in tumour neovascularization. In this study, we have investigated the expression of VEGF and PGE-2 in 53 canine cutaneous mast cell tumours (MCTs). Immunohistochemistry of tissue sections revealed that VEGF and PGE-2 were expressed in all mast cell tumours studied. When the expression patterns of VEGF and PGE-2 were compared with tumour grade according to Patnaik criteria, the only significant correlation observed was between PGE-2 staining intensity and tumour pathological grade, with grade II and III tumours having higher PGE-2 staining, both in intensity and percentage of cells stained, than grade I tumours (P < 0.05).

摘要

血管内皮生长因子（VEGF）和前列腺素 E2（PGE-2）似乎在肿瘤新生血管形成中发挥着关键作用。在这项研究中，我们调查了 53 例犬皮肤肥大细胞瘤（MCT）中 VEGF 和 PGE-2 的表达。组织切片的免疫组织化学显示，研究中的所有肥大细胞瘤均表达 VEGF 和 PGE-2。当根据 Patnaik 标准将 VEGF 和 PGE-2 的表达模式与肿瘤分级进行比较时，唯一观察到的显著相关性是 PGE-2 染色强度与肿瘤病理分级之间的相关性，II 级和 III 级肿瘤的 PGE-2 染色强度和染色细胞百分比均高于 I 级肿瘤（P < 0.05）。