Department of Veterinary Medicine, The Queen's Veterinary School Hospital, University of Cambridge, Madingley Road, Cambridge, UK.
Vet Comp Oncol. 2010 Dec;8(4):263-72. doi: 10.1111/j.1476-5829.2010.00220.x. Epub 2010 Oct 13.
Tumour suppressor in lung cancer-1 (TSLC1) is a tumour-suppressor gene coding for an adhesion molecule that is expressed by mast cells. Reduced TSLC1 expression is associated with a poor prognosis in several human tumours, and this study sought to investigate if TSLC1 expression could be used to predict outcome in dogs with mast cell tumours (MCTs). Sections of MCTs of different tumour grades from 45 dogs (Group 1) were immunohistochemically assessed for TSLC1 and Ki67 expression. In addition, 35 intermediate-grade MCTs (Group 2) from dogs with known clinical follow-up were immunohistochemically stained for TSLC1 and Ki67. The TSLC1 staining intensity was found to strongly inversely correlate with tumour grade for Group 1 (P = 0.002857). For Group 2 there was a trend towards dogs with lower TSLC1 scores being more likely to die from MCT-related disease (P = 0.058). The intensity of TSLC1 staining inversely correlated with Ki67 expression for both groups.
肺癌肿瘤抑制因子 1（TSLC1）是一种抑癌基因，编码一种黏附分子，由肥大细胞表达。在几种人类肿瘤中，TSLC1 表达降低与预后不良相关，本研究旨在探讨 TSLC1 表达是否可用于预测犬肥大细胞瘤（MCT）的预后。对 45 只狗（第 1 组）不同肿瘤分级的 MCT 切片进行免疫组织化学评估，以检测 TSLC1 和 Ki67 的表达情况。此外，对 35 例已知临床随访的中等级别 MCT（第 2 组）进行了 TSLC1 和 Ki67 的免疫组织化学染色。结果发现，第 1 组的 TSLC1 染色强度与肿瘤分级呈强烈负相关（P = 0.002857）。对于第 2 组，TSLC1 评分较低的狗更有可能死于与 MCT 相关的疾病，这一趋势具有统计学意义（P = 0.058）。两组的 TSLC1 染色强度与 Ki67 表达呈负相关。
