Department of Microbiology, Immunology, and Pathology, Diagnostic Medicine Center, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523-1619, USA.
Vet Comp Oncol. 2010 Mar;8(1):72-9. doi: 10.1111/j.1476-5829.2009.00206.x.
This case series presents a unique and unreported variant of feline intestinal mast cell tumour recognized at the CSU Veterinary Diagnostic Laboratory. Fifty cases of feline intestinal mast cell tumours described as having a significant stromal component were reviewed. Neoplastic cells formed a trabecular pattern admixed with moderate to abundant dense stromal collagen (sclerosis). Neoplastic cells had poorly discernible intracytoplasmic granules which demonstrated metachromasia with special histochemical stains consistent with mast cell granules. Additionally, a subset of cases stained for mast cell-specific tryptase and c-kit demonstrated positive immunoreactivity. Eosinophilic infiltrates were moderate to marked in almost all cases. Lymph node and hepatic metastases were present in 66% of the cases. Treatment and clinical outcome was available in 25/50 cases. Twenty-three of these patients died or were euthanized within 2 months of initial diagnosis. This is the first case series to characterize a sclerosing variant of intestinal mast cell tumour in the cat which appears to have a high propensity for metastasis and a guarded prognosis.
本病例系列介绍了 CSU 兽医诊断实验室识别到的一种独特且未曾报道的猫肠道肥大细胞瘤变体。对 50 例被描述为具有显著基质成分的猫肠道肥大细胞瘤进行了回顾。肿瘤细胞形成了与中等至丰富致密的基质胶原（硬化）混合的小梁模式。肿瘤细胞的细胞质内颗粒难以分辨，特殊组织化学染色显示与肥大细胞颗粒一致的异染性。此外，一部分病例的肥大细胞特异性胰蛋白酶和 c-kit 染色显示阳性免疫反应。几乎所有病例的嗜酸性粒细胞浸润均为中度至重度。66%的病例存在淋巴结和肝转移。在 50 例中有 25 例可获得治疗和临床结果。这些患者中有 23 例在初始诊断后 2 个月内死亡或安乐死。这是首例描述猫肠道肥大细胞瘤硬化变体的病例系列，该变体似乎具有高度转移倾向和预后不良。
