BCL6 和 BCoR 联合 Notch 调控左右模式形成。

BCL6 and BCoR gang up on Notch to regulate left-right patterning.

机构信息

Ecole Polytechnique Fédérale de Lausanne, Swiss Institute for Experimental Cancer Research, Station 19, 1015 Lausanne, Switzerland.

出版信息

Dev Cell. 2010 Mar 16;18(3):338-40. doi: 10.1016/j.devcel.2010.03.001.

DOI:10.1016/j.devcel.2010.03.001

PMID:20230742

Abstract

In this issue of Developmental Cell, Sakano et al. describe a novel mechanism of how a key lymphocyte transcription factor crosstalks to Notch signaling during embryonic development and thereby selectively inhibits Notch-activated target genes to allow proper left-right patterning.

摘要

在本期《发育细胞》中，Sakano 等人描述了一种新的机制，即关键淋巴细胞转录因子如何在胚胎发育过程中与 Notch 信号通路相互作用，从而选择性地抑制 Notch 激活的靶基因，以确保左右模式的正常形成。