Dunwoodie Sally L
Developmental Biology Division, Victor Chang Cardiac Research Institute, 405 Liverpool Street, Darlinghurst, NSW 2010 Sydney, Australia.
Curr Opin Genet Dev. 2009 Aug;19(4):329-37. doi: 10.1016/j.gde.2009.06.005. Epub 2009 Jul 14.
The components of the Notch signaling pathway and the mechanics of signal transduction have largely been established in Drosophila. Although essential for many developmental processes in invertebrates and vertebrates, this review focuses on Notch signaling in the vertebrate-specific process of somitogenesis. More specifically it describes that mutations in genes encoding Notch pathway components (DLL3, MESP2, LFNG and HES7) cause severe congenital vertebral defects in humans. Importantly, this review highlights studies demonstrating that Dll3 is unique amongst DSL ligands acting as an inhibitor and not an activator of Notch signaling.
Notch信号通路的组成部分以及信号转导机制在很大程度上已在果蝇中得到确立。尽管该信号通路对无脊椎动物和脊椎动物的许多发育过程至关重要，但本综述聚焦于脊椎动物特有的体节发生过程中的Notch信号通路。更具体地说，它描述了编码Notch信号通路组成部分的基因（DLL3、MESP2、LFNG和HES7）发生突变会导致人类出现严重的先天性脊椎缺陷。重要的是，本综述强调了一些研究，这些研究表明Dll3在DSL配体中是独特的，它作为Notch信号的抑制剂而非激活剂发挥作用。
