University of Kansas, Lawrence, KS 66047, USA.
J Pediatr Psychol. 2010 Oct;35(9):1016-27. doi: 10.1093/jpepsy/jsq014. Epub 2010 Mar 15.
To examine medication adherence trajectories posttransplantation and the association between adherence trajectories and self-reported internalizing symptoms in a pediatric population.
Multilevel modeling was used to examine internalizing symptoms and longitudinal medication adherence, as assessed by electronic monitoring, among 55 children and adolescents who received liver or kidney transplantation.
Medication adherence generally declined over the study assessment window, and higher levels of anxiety were associated with higher and more stable patterns of medication adherence.
Anxiety may be an important factor to consider when assessing and intervening with posttransplantation medication adherence. Future research should consider the potential reactivity effects of adherence monitoring, as well as individual and family behaviors associated with anxiety that may influence adherence.
研究移植后药物依从性轨迹与儿童人群中依从性轨迹与自我报告的内化症状之间的关系。
使用多层次模型来研究 55 名接受肝或肾移植的儿童和青少年的内化症状和纵向药物依从性，通过电子监测进行评估。
药物依从性总体上在研究评估窗口期间下降，较高的焦虑水平与更高和更稳定的药物依从性模式相关。
在评估和干预移植后药物依从性时，焦虑可能是一个重要的考虑因素。未来的研究应考虑依从性监测的潜在反应性影响，以及可能影响依从性的与焦虑相关的个体和家庭行为。
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