García-Alvarez Lara, Oteo José Antonio
Área de Enfermedades Infecciosas, Hospital San Pedro-Centro de Investigación Biomédica de La Rioja, Logroño, Spain.
Rev Esp Quimioter. 2010 Mar;23(1):4-11.
Tetracyclines are a family of antibiotics very common in clinical practice that have been used in not infectious affections. One of their most studied actions is their ability to inhibit matrix metalloproteinases (MMPs), a group of proteinases that have been implicated in pathological processes as oncogenesis and inflammation. Tetracyclines have been shown to play an important role in malignant angiogenesis and cancer invasion, which is related with tumor aggressiveness and metastatic potential.They also show anti-inflammatory activity in neurological, respiratory, bone and heart diseases, and in rheumatologic and dermatologic processes. The aim of this review is to make an updating about the non antimicrobial actions of tetracyclines, specially their therapeutic applications in different diseases.
四环素是临床实践中非常常见的一类抗生素，已被用于非感染性疾病。其研究最多的作用之一是抑制基质金属蛋白酶（MMPs）的能力，基质金属蛋白酶是一组与肿瘤发生和炎症等病理过程有关的蛋白酶。四环素已被证明在恶性血管生成和癌症侵袭中起重要作用，这与肿瘤侵袭性和转移潜能有关。它们在神经、呼吸、骨骼和心脏疾病以及风湿和皮肤疾病中也表现出抗炎活性。本综述的目的是更新四环素的非抗菌作用，特别是其在不同疾病中的治疗应用。
