Department of Pediatrics, Chang Gung Children's Hospital, Chang Gung University, Taoyuan, Taiwan.
Int J Hematol. 2010 May;91(4):705-7. doi: 10.1007/s12185-010-0548-2. Epub 2010 Mar 17.
This report described unrelated umbilical cord blood transplantation for a 3-year-old girl with myelodysplastic syndrome and monosomy 7. The patient had a prolonged course characterized by recurrent infection and slowly progressive pancytopenia. She had reduced numbers of circulating B cells but no decline in immunoglobulin levels. Chemotherapy was not initially recommended because it was contraindicated due to intercurrent lower respiratory tract infection. After 10 months, the girl achieved hematologic remission after induction chemotherapy. The patient then underwent 2-loci HLA-mismatched unrelated donor cord blood transplantation. The time to neutrophil and platelet engraftment was 12 and 23 days post-transplantation, respectively. Acute graft-versus-host disease following transplantation was minimal. She was in continuing hematological remission with full donor chimerism 3 years after transplantation.
本报告描述了一例 3 岁女性患有骨髓增生异常综合征伴 7 号单体的非相关脐带血移植。该患者病程迁延，表现为反复感染和进行性全血细胞减少。她外周血循环 B 细胞数量减少，但免疫球蛋白水平没有下降。最初不建议化疗，因为并发下呼吸道感染而禁忌。10 个月后，患者经诱导化疗后达到血液学缓解。然后患者接受了 2 个 HLA 错配的非亲缘脐带血移植。移植后中性粒细胞和血小板植入的时间分别为 12 天和 23 天。移植后急性移植物抗宿主病较轻。移植后 3 年，患者持续处于血液学缓解状态，完全供者嵌合。
