Domper M, Richter J A, Lacruz F, Arbizu J, Manubens J M, García M J, Martínez-Lage M
Servicios de Medicina Nuclear, Clínica Universitaria de Navarra, Pamplona.
Med Clin (Barc). 1991 Jan 12;96(1):1-5.
Brain single photon emission computed tomography (SPECT) with 99mTc-HMPAO is a diagnostic tool for evaluating regional cerebral blood flow. Recently, the diagnostic possibilities of the method are being investigated in some neurologic disorders, such as cerebrovascular accidents, seizures and dementia. This work has been carried out with 54 subjects, 9 healthy volunteers and 45 patients (31 dementia and 14 epileptics), in order to evaluate gammagraphic patterns and the utility of cortico/cerebellar activity indexes. An interesting diagnostic finding is a significant decrease (p less than 0.001) in perfusion of temporoparietal regions in the patients with Alzheimer's disease in relation with the healthy volunteers' group. We have not found significant changes in perfusion in the group of epileptic patients during the interictal phase. We conclude emphasizing the interest of the SPECT in the differential diagnosis of dementia.
采用99mTc-HMPAO的脑单光子发射计算机断层扫描（SPECT）是一种评估局部脑血流量的诊断工具。最近，该方法在一些神经系统疾病，如脑血管意外、癫痫和痴呆症中的诊断可能性正在被研究。这项研究对54名受试者进行，其中包括9名健康志愿者和45名患者（31名痴呆症患者和14名癫痫患者），以评估γ射线扫描模式以及皮质/小脑活动指数的效用。一个有趣的诊断发现是，与健康志愿者组相比，阿尔茨海默病患者颞顶叶区域的灌注显著降低（p<0.001）。我们未发现癫痫患者组在发作间期灌注有显著变化。我们强调SPECT在痴呆症鉴别诊断中的重要性并得出结论。
