（+）-海鞘素的全合成，通过 Zr 催化的不对称烯丙基碳铝化反应（ZACA）实现手性和高效的侧链合成路线。
Total synthesis of (+)-scyphostatin featuring an enantioselective and highly efficient route to the side-chain via Zr-catalyzed asymmetric carboalumination of alkenes (ZACA).
机构信息
Laboratory of Natural Products Synthesis & Bioorganic Chemistry, Institute of Physical Chemistry, NCSR DEMOKRITOS, P.O. Box 60228, GR 153 10, Aghia Paraskevi, Greece.
出版信息
Chem Commun (Camb). 2010 Apr 7;46(13):2200-2. doi: 10.1039/b920261g. Epub 2010 Feb 23.
DOI:10.1039/b920261g
PMID:20234905
Abstract
(+)-Scyphostatin (1) was synthesized via (i) construction of a side-chain 3b of > or = 98% purity in 19% yield in eleven steps featuring ZACA reaction, Negishi coupling, and HWE olefination, (ii) an asymmetric synthesis of a fully protected core 4 from 10a, and (iii) a three-step assembly of 1 in 42% yield.
摘要
(+)-Scyphostatin（1）通过以下步骤合成：（i）以 19%的产率经 ZACA 反应、Negishi 偶联和 HWE 烯烃化反应，立体选择性地构建 >或=98%纯度的侧链 3b，共 11 步；（ii）从 10a 不对称合成全保护核心 4；（iii）经三步组装得到 1，产率为 42%。
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