Department of Pharmacy and Therapeutics, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA.
Clin Infect Dis. 2010 May 1;50(9):1258-67. doi: 10.1086/651603.
Currently, only 2 drugs have been approved for the treatment of respiratory syncytial virus (RSV). Palivizumab is a monoclonal antibody for the prevention of RSV in high-risk children. Ribavirin is approved for treatment of severe RSV disease; however, its effectiveness in improving outcomes is questionable. During the past 40 years, many obstacles have delayed the development of safe and effective vaccines and treatment regimens. This article reviews these obstacles and presents the novel development strategies used to overcome many of them. Also discussed are promising new antiviral treatment candidates and their associated mechanism of action, the significant advances made in vaccine development, and exciting, new studies directed at improving outcomes through pharmacologic manipulation of the host response to RSV disease.
目前,仅有 2 种药物被批准用于治疗呼吸道合胞病毒(RSV)。帕利珠单抗是一种用于预防高危儿童 RSV 的单克隆抗体。利巴韦林被批准用于治疗严重 RSV 疾病;然而,其改善结局的效果是有疑问的。在过去的 40 年中,许多障碍阻碍了安全有效的疫苗和治疗方案的发展。本文综述了这些障碍,并介绍了用于克服其中许多障碍的新的开发策略。还讨论了有前途的新型抗病毒治疗候选药物及其相关作用机制、疫苗开发方面的重大进展,以及通过对 RSV 疾病宿主反应的药物干预来改善结局的令人兴奋的新研究。