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降低老年髋部骨折患者的谵妄发生率:一项多因素干预研究。

Reducing delirium in elderly patients with hip fracture: a multi-factorial intervention study.

作者信息

Björkelund K B, Hommel A, Thorngren K-G, Gustafson L, Larsson S, Lundberg D

机构信息

Department of Anesthesiology and Intensive Care, Clinical Sciences, Lund University, Lund, Sweden.

出版信息

Acta Anaesthesiol Scand. 2010 Jul;54(6):678-88. doi: 10.1111/j.1399-6576.2010.02232.x. Epub 2010 Mar 15.

Abstract

BACKGROUND

There is an evident need for improved management of elderly patients with trauma in order to avoid common and troublesome complications such as delirium. The aim of this study was to investigate whether an implementation of a multi-factorial program including intensified pre-hospital and perioperative treatment and care could reduce the incidence of delirium in elderly patients with hip fracture, cognitively intact at admission to the hospital. In addition, we explored the factors that characterize patients who developed delirium.

METHODS

A prospective, quasi-experimental design was used. A total of 263 patients with hip fracture (> or = 65 years), cognitively intact at admission, were consecutively included between April 2003 and April 2004. On 1 October 2003, a new program was introduced. All patients were screened for cognitive impairment within 30 min after admission to the emergency department using The Short Portable Mental Status Questionnaire (SPMSQ). To screen for delirium, patients were tested within 4 h of admission and thereafter daily, using the Organic Brain Syndrome scale.

RESULTS

The number of patients who developed delirium during hospitalization was 74 (28.1%), with a decrease from 34% (45 of 132) in the control group to 22% (29 of 131) in the intervention group (P=0.031). Patients who developed delirium were statistically older, more often had > 4 prescribed drugs at admission and scored less well in the SPMSQ test.

CONCLUSION

The use of a multi-factorial intervention program in elderly hip fracture patients, lucid at admission, reduced the incidence of delirium during hospitalization by 35%.

摘要

背景

为避免诸如谵妄等常见且棘手的并发症,明显需要改进对老年创伤患者的管理。本研究的目的是调查实施一项包括强化院前及围手术期治疗与护理的多因素方案是否能降低入院时认知功能正常的老年髋部骨折患者谵妄的发生率。此外,我们还探究了发生谵妄的患者的特征因素。

方法

采用前瞻性、准实验设计。2003年4月至2004年4月期间,连续纳入了总共263例入院时认知功能正常的髋部骨折患者(年龄≥65岁)。2003年10月1日,引入了一项新方案。所有患者在急诊科入院后30分钟内使用简易便携式精神状态问卷(SPMSQ)进行认知障碍筛查。为筛查谵妄,患者在入院后4小时内进行测试,此后每天使用器质性脑综合征量表进行测试。

结果

住院期间发生谵妄的患者有74例(28.1%),发生率从对照组的34%(132例中的45例)降至干预组的22%(131例中的29例)(P=0.031)。发生谵妄的患者在统计学上年龄更大,入院时经常服用超过4种处方药,且在SPMSQ测试中的得分较低。

结论

对入院时神志清醒的老年髋部骨折患者使用多因素干预方案,可使住院期间谵妄的发生率降低35%。

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