慢性肝病患者的氨基酸失衡。

Amino acid imbalance in patients with chronic liver diseases.

机构信息

Department of Gastroenterology, Ehime Prefectural Central Hospital, Matsuyama.

出版信息

Hepatol Res. 2010 Apr;40(4):393-8. doi: 10.1111/j.1872-034X.2009.00614.x. Epub 2010 Mar 4.

DOI:10.1111/j.1872-034X.2009.00614.x

PMID:20236360

Abstract

AIM

The aim of this study is to clarify the amino acid imbalance in patients with chronic hepatitis (CH) as well as those with liver cirrhosis (LC).

METHODS

We assayed total branched-chain amino acids (BCAA), tyrosine (Tyr) levels and their ratio (BTR) in sera of 101 patients with CH (37 in fibrosis stage F1, 23 in F2, 21 in F3) and 20 with LC (F4) who were diagnosed by liver biopsy. Their levels in relation to the staging of liver fibrosis were analyzed.

RESULTS

The percentage of patients whose BTR was less than the normal range was 32.1% in CH and 75.0% in LC. The levels of BTR and BCAA were significantly lower (P < 0.001, P < 0.05, respectively) and that of Tyr was significantly higher (P < 0.001) in patients with LC than those in CH. The levels of BTR decreased according to the staging. The levels of Tyr increased according the staging, whereas the levels of BCAA deceased prominently in F4 (487 +/- 103 in F1, 483 +/- 122 in F2, 487 +/- 111 in F3 and 423 +/- 94 in F4).

CONCLUSION

A considerable number of patients not only with LC but also with CH showed lower levels of BTR. It has been clarified that amino acid imbalance of Tyr was found in the early stage of liver disease, whereas decrease of BCAA was found mainly in F4 stage.

摘要

目的

本研究旨在阐明慢性肝炎（CH）和肝硬化（LC）患者的氨基酸失衡情况。

方法

我们检测了 101 例 CH 患者（纤维化分期 F1 期 37 例，F2 期 23 例，F3 期 21 例）和 20 例 LC 患者（F4 期）血清中总支链氨基酸（BCAA）、酪氨酸（Tyr）水平及其比值（BTR），并通过肝活检进行诊断。分析其与肝纤维化分期的关系。

结果

BTR 低于正常范围的患者在 CH 中占 32.1%，在 LC 中占 75.0%。LC 患者的 BTR 和 BCAA 水平显著降低（P < 0.001，P < 0.05），Tyr 水平显著升高（P < 0.001），而 CH 患者的 BTR 和 BCAA 水平显著降低（P < 0.001，P < 0.05）。BTR 水平随分期降低而降低。Tyr 水平随分期升高而升高，而 BCAA 水平在 F4 期显著降低（F1 期为 487 ± 103，F2 期为 483 ± 122，F3 期为 487 ± 111，F4 期为 423 ± 94）。