一名47岁患有严重乳腺上皮增生且正在服用布洛芬的女性，其用于检测增殖情况的放射性示踪剂锝-99m标记的五价二巯基琥珀酸摄取减少：病例报告
Reduced uptake of the proliferation-seeking radiotracer technetium-99m-labelled pentavalent dimercaptosuccinic acid in a 47-year-old woman with severe breast epithelial hyperplasia taking ibuprofen: a case report.
作者信息
Papantoniou Vassilios J, Sotiropoulou Evangelia K, Valsamaki Pipitsa N, Tsaroucha Angeliki G, Sotiropoulou Maria G, Ptohis Nikolaos D, Stipsanelli Aikaterini J, Dimitrakakis Konstantinos E, Marinopoulos Spyridon G, Tsiouris Spyridon T, Antsaklis Aris J
机构信息
Department of Nuclear Medicine, Alexandra University Hospital, Vasilissis Sofias Avenue, Athens, 11528, Greece.
出版信息
J Med Case Rep. 2010 Mar 17;4:89. doi: 10.1186/1752-1947-4-89.
INTRODUCTION
Recent studies have reported a risk reduction in the progression of benign breast disease to breast carcinoma through COX-2 pathways.
CASE PRESENTATION
We present a case of severe epithelial hyperplasia in a 47-year-old woman with increased breast density submitted to scintimammography by the proliferation-imaging tracer Technetium-99m-labelled pentavalent dimercaptosuccinic acid, before and after an oral ibuprofen treatment for 4 weeks. The radiotracer uptake after ibuprofen intake was significantly reduced, both visually and by semi-quantitative analysis, based on a calculation of lesion-to-background ratios.
CONCLUSION
In proliferating breast lesions, scintigraphically displayed reduction in Technetium-99m-labelled pentavalent dimercaptosuccinic acid uptake may indicate inhibition by ibuprofen in the pathway of malignant epithelial cell transformation.
引言
最近的研究报告称，通过COX - 2途径可降低良性乳腺疾病进展为乳腺癌的风险。
病例报告
我们报告一例47岁女性严重上皮增生病例，该女性乳腺密度增加，在口服布洛芬治疗4周前后，通过增殖显像剂锝 - 99m标记的五价二巯基琥珀酸进行乳腺闪烁显像。基于病变与背景比值的计算，布洛芬摄入后，放射性示踪剂摄取在视觉上和半定量分析中均显著降低。
结论
在增殖性乳腺病变中，闪烁显像显示锝 - 99m标记的五价二巯基琥珀酸摄取减少，可能表明布洛芬对恶性上皮细胞转化途径有抑制作用。
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