Nuclear Medicine Department, "Alexandra" University Hospital, 80 Vassilisis Sophias' Avenue, Athens 11528, Greece.
Mol Imaging. 2010 Oct;9(5):233-6.
The purpose of this study was to investigate if ibuprofen intake can influence mammary uptake of the proliferation-seeking radiotracer technetium 99m-pentavalent dimercaptosuccinic acid (99mTc-(V)DMSA) in women with severe epithelial and atypical epithelial breast hyperplasia. Eight patients with histologically confirmed severe epithelial breast hyperplasia with (n = 4) and without atypia (n = 4) were submitted prospectively to 99mTc-(V)DMSA scintimammography before and after a 4-week course of 400 mg ibuprofen daily oral intake. Lesion to background ratios 60 minutes postinjection were calculated and compared (t-test) before and after ibuprofen administration. Prior to ibuprofen, the patients with severe epithelial hyperplasia displayed a significantly higher 99mTc-(V)DMSA uptake ratio compared to those with atypical epithelial hyperplasia (2.40 ± 0.32 vs 1.67 ± 0.09, respectively; p = .003). They also exhibited a more substantial percent decline in tracer uptake postibuprofen compared to women with atypical epithelial hyperplasia (62.0 ± 7.1 vs 15.0 ± 0.2, respectively; p = .001). Ibuprofen induces significant uptake reduction of the proliferation-seeking radiotracer 99mTc-(V)DMSA in severe epithelial breast hyperplasia without atypia. This agent could therefore constitute a potential imaging tool for monitoring chemoprophylaxis effectiveness in women at the early stages of malignant transformation.
本研究旨在探讨布洛芬摄入是否会影响女性严重上皮性和非典型上皮性乳腺增生患者乳腺对放射性示踪剂锝 99m-五价二巯丁二酸（99mTc-（V）DMSA）的摄取。8 例经组织学证实的严重上皮性乳腺增生患者（n=4 例伴不典型增生，n=4 例不伴不典型增生）前瞻性接受 99mTc-（V）DMSA 闪烁乳腺扫描，在 4 周 400mg 布洛芬每日口服摄入前后进行。注射后 60 分钟计算病变与背景的比值，并在布洛芬给药前后进行比较（t 检验）。在服用布洛芬之前，严重上皮性增生患者的 99mTc-（V）DMSA 摄取比值明显高于非典型上皮性增生患者（分别为 2.40±0.32 和 1.67±0.09；p=0.003）。与非典型上皮性增生患者相比，服用布洛芬后，这些患者的示踪剂摄取量下降幅度更大（分别为 62.0±7.1%和 15.0±0.2%；p=0.001）。布洛芬可显著减少无不典型增生的严重上皮性乳腺增生中增殖性放射性示踪剂 99mTc-（V）DMSA 的摄取。因此，该药物可能成为监测女性恶性转化早期阶段化学预防效果的潜在影像学工具。
