基于联萘基的三肽的合成及抗菌研究。第 1 部分。
Synthesis and antibacterial studies of binaphthyl-based tripeptoids. Part 1.
机构信息
School of Chemistry, University of Wollongong, Wollongong, NSW 2522, Australia.
出版信息
Bioorg Med Chem. 2010 Apr 1;18(7):2611-20. doi: 10.1016/j.bmc.2010.02.033. Epub 2010 Feb 23.
PMID:20236828
Abstract
An efficient synthesis of 29 new binaphthyl-based neutral, and mono- and di-cationic, peptoids is described. Some of these compounds had antibacterial activities with MIC values of 1.9-3.9microg/mL against Staphylococcus aureus. One peptoid had a MIC value of 6microg/mL against a methicillin-resistant strain of S. aureus (MRSA) and a MIC value of 2microg/mL against vancomycin-resistant strains of enterococci (VRE).
摘要
本文描述了 29 种新型联萘基中性、单阳离子和双阳离子肽的高效合成。其中一些化合物具有抗菌活性，对金黄色葡萄球菌的 MIC 值为 1.9-3.9μg/mL。一种肽对耐甲氧西林金黄色葡萄球菌（MRSA）的 MIC 值为 6μg/mL，对万古霉素耐药肠球菌（VRE）的 MIC 值为 2μg/mL。
Zotero 插件