Bégin-Heick N, Heick H M
Can J Physiol Pharmacol. 1977 Dec;55(6):1320-9. doi: 10.1139/y77-177.
The activity of the lipolytic system of the obese hyperglycemic mouse was assessed after treatment with physiological doses of thyroxin (T4). The treatment significantly increased fatty acid mobilization in response to adrenaline over the levels observed in the control mice under all conditions studied. The activities of the high- and low-Km phosphodiesterases and of adenylate cyclase were also studied. Treatment of the ob/ob mice with T4 had little effect on the activities of the cyclic AMP phosphodiesterases (high and low Km) but it partially restored the activity of adenylate cyclase, which is deficient in these animals. A correlation was found in the T4-treated obese animals between the ability of the epididymal adipose tissue to mobilize fatty acids, its ability to increase the intracellular levels of cyclic AMP, and the activity of adenylate cyclase in response to adrenaline stimulation.
用生理剂量的甲状腺素（T4）治疗后，对肥胖高血糖小鼠的脂解系统活性进行了评估。在所有研究条件下，该治疗均使肾上腺素刺激下的脂肪酸动员显著高于对照小鼠的水平。还研究了高Km和低Km磷酸二酯酶以及腺苷酸环化酶的活性。用T4治疗ob/ob小鼠对环磷酸腺苷磷酸二酯酶（高Km和低Km）的活性影响不大，但部分恢复了这些动物中缺乏的腺苷酸环化酶的活性。在经T4治疗的肥胖动物中，发现附睾脂肪组织动员脂肪酸的能力、其增加细胞内环磷酸腺苷水平的能力以及对肾上腺素刺激的腺苷酸环化酶活性之间存在相关性。
