Michalak E, Walkowiak B, Paradowski M, Cierniewski C S
Department of Nephrology, Medical School, Lodz, Poland.
Thromb Haemost. 1991 Jan 23;65(1):11-4.
The mean platelet volume, measured optically and by the electrical impedance method, was analysed in the patients with chronic renal failure. All parameters describing the circulating platelet biomass except the platelet volume heterogeneity were decreased in these patients. There is a strong inverse relation between the Ivy bleeding time and the platelet mass in the patient group. Our results indicate that the smaller platelets circulating in the patients with chronic renal failure may contribute to the uremic bleeding diathesis, and disturbed thrombocytopoiesis occurs in chronic renal failure.
采用光学法和电阻抗法测量慢性肾衰竭患者的平均血小板体积，并进行分析。除血小板体积异质性外，这些患者中描述循环血小板生物量的所有参数均降低。在该患者组中，Ivy出血时间与血小板数量之间存在很强的负相关关系。我们的结果表明，慢性肾衰竭患者体内循环的较小血小板可能导致尿毒症出血倾向，且慢性肾衰竭时存在血小板生成紊乱。
