Strassman H D
Compr Ther. 1978 Jan;4(1):61-6.
Sleep is a vital human physiologic process. Insomnia can be caused by obsession and depression states, pain, or worry over everyday problems. Because of their pharmacologic action, alcohol and high doses of soporifics used as remedies may produce REM-deficit sleep and actually prolong insomnia. If the true cause of sleeplessness is not recognized and properly treated, insomnia may develop into a severe sleep problem. Since benzodiazepines and chloral hydrate do not suppress REM sleep, they are the medications of choice in the therapy for insomnia.
睡眠是人类至关重要的生理过程。失眠可能由强迫观念与抑郁状态、疼痛或对日常问题的担忧引起。由于酒精和用作治疗药物的高剂量安眠药具有药理作用,它们可能会导致快速眼动睡眠缺失,并实际上延长失眠时间。如果失眠的真正原因未被识别和正确治疗,失眠可能会发展成严重的睡眠问题。由于苯二氮䓬类药物和水合氯醛不会抑制快速眼动睡眠,它们是治疗失眠的首选药物。