Patterns of cyclic 3'5'-adenosine monophosphate excretion in parathyroid dysfunction.

The pattern of excretion of cyclic 3'5' adenosine monophosphate (cAMP) over 24 h was evaluated in nine hyperparathyroid, four hypoparathyroid and three postoperative hyperparathyroid patients. The hyperparathyroid patients had increased excretion at the time of the normal nadir and were normal or low occasionally during the day. The pattern in the hypoparathyroid and in the postoperative patients also differed from normal. These findings suggest that both peaks of urinary cAMP excretion found in normal individuals result from the effects of parathyroid hormone on the kidneys.