Shibaya M, Kubomichi M, Watanabe T
Tokyo University of Agriculture, Japan.
Vet Microbiol. 1991 Feb 1;26(3):309-12. doi: 10.1016/0378-1135(91)90024-a.
Inbred mice of the C3H/He (resistant) and C57BL/6 (susceptible) strains and their hybrids were used in experiments to investigate the genetic regulation of host resistance to B. anthracis. The susceptibility of F1 mice to a standard spore suspension was similar to that of the resistant parent and not intermediate between values for the parent strains. There were no differences in mortality rate between F1 and reciprocal cross mice. Analysis of the results indicated that resistance of mice to B. anthracis is regulated by a single dominant gene.
采用C3H/He（抗性）和C57BL/6（敏感）品系的近交系小鼠及其杂交后代进行实验，以研究宿主对炭疽杆菌抗性的遗传调控。F1代小鼠对标准芽孢悬液的敏感性与抗性亲代相似，而非介于两个亲本品系的值之间。F1代小鼠和正反交小鼠的死亡率没有差异。结果分析表明，小鼠对炭疽杆菌的抗性由单个显性基因调控。
