Meloni T, Forteleoni G, Noja G, Dettori G, Sale M A, Meloni G F
Clinica Pediatrica A. Filia Università, Sassari, Italia.
Acta Haematol. 1991;85(2):76-8. doi: 10.1159/000204861.
The glucose-6-phosphate dehydrogenase (G6PD) enzyme activity was determined in 299 Northern Sardinian patients with cholelithiasis. Sixteen (12.80%) of the 125 male patients studied were G6PD deficient; 33 (18.96%) of the 174 females were heterozygous and 1 (0.57%) homozygous. Thus, the prevalence of G6PD deficiency in male subjects with cholelithiasis is about 35% higher (p less than 0.02) than that of a normal male control group (7.29%). As regards female patients, the incidence of the GdMed allele was also significantly different (p less than 0.05). Thus, G6PD-deficient subjects may have a predisposition to develop gallstones, even in the absence of clinical signs of chronic hemolysis.
对299名撒丁岛北部胆结石患者进行了葡萄糖-6-磷酸脱氢酶（G6PD）酶活性检测。在125名接受研究的男性患者中，有16名（12.80%）G6PD缺乏；在174名女性患者中，33名（18.96%）为杂合子，1名（0.57%）为纯合子。因此，胆结石男性患者中G6PD缺乏的患病率比正常男性对照组（7.29%）高约35%（p<0.02）。对于女性患者，GdMed等位基因的发生率也有显著差异（p<0.05）。因此，即使没有慢性溶血的临床症状，G6PD缺乏的个体也可能易患胆结石。
