Kent A P, Hunter J M
University Department of Anaesthesia, Royal Liverpool Hospital.
Anaesthesia. 1991 Apr;46(4):271-4. doi: 10.1111/j.1365-2044.1991.tb11494.x.
Alcuronium (0.2 mg/kg) was given to 12 elderly patients, mean age 77 years (range 70-88 years) and 12 young patients, mean age 24 years (range 18-32 years) undergoing general anaesthesia. A compound muscle action potential was monitored continuously throughout anaesthesia, using an electromyograph and the train-of-four twitch technique. The rate of onset and maximum block achieved were similar in both the young and elderly patients, as were the times to 20% recovery of the first twitch compared with control (T1 : T0) and fourth twitch compared with the first, (T4 : T1). In contrast, the time to 70% recovery of T1 : T0 was significantly prolonged in the elderly (138 as compared with 89 minutes: p less than 0.01) as was the recovery index (25-75%) for T1 : T0 (95 as compared with 46 minutes: p less than 0.01) and the time to 70% recovery of T4 : T1 (181 as compared with 131 minutes: p less than 0.05). The recovery curves for T1 : T0 and T4 : T1 were also significantly different in the elderly from the young group (p less than 0.01 in both instances). These results show that the duration of action of alcuronium is significantly prolonged in the elderly.
将阿库氯铵（0.2毫克/千克）给予12例老年患者（平均年龄77岁，范围70 - 88岁）和12例年轻患者（平均年龄24岁，范围18 - 32岁），这些患者均接受全身麻醉。在整个麻醉过程中，使用肌电图和四个成串刺激技术持续监测复合肌肉动作电位。年轻患者和老年患者的起效速度和达到的最大阻滞程度相似，与对照相比，第一个肌颤搐恢复到20%的时间（T1 : T0）以及第四个肌颤搐与第一个相比恢复到20%的时间（T4 : T1）也相似。相比之下，老年患者T1 : T0恢复到70%的时间显著延长（138分钟，而年轻患者为89分钟：p < 0.01），T1 : T0的恢复指数（25 - 75%）也是如此（95分钟，而年轻患者为46分钟：p < 0.01），T4 : T1恢复到70%的时间也是老年患者更长（181分钟，而年轻患者为131分钟：p < 0.05）。老年组T1 : T0和T4 : T1的恢复曲线与年轻组也有显著差异（两种情况p均< 0.01）。这些结果表明，阿库氯铵在老年患者中的作用持续时间显著延长。
