Peña C, Medina J H, Piva M, Diaz L E, Danilowicz C, Paladini A C
Instituto de Biología Celular, Facultad de Medicina, (UBA-CONICET), Buenos Aires, Argentina.
Biochem Biophys Res Commun. 1991 Mar 29;175(3):1042-50. doi: 10.1016/0006-291x(91)91670-8.
The presence of benzodiazepine-like molecules was detected radioimmunologically in the plasma and milk of 12 women and in the plasma of 9 men. All subjects were non-users of benzodiazepines. The concentration of these biological materials expressed as diazepam equivalents per mL amounted to 2.54 +/- 0.74 ng in male plasma; to 2.20 +/- 0.35 ng in female plasma and to 1.91 +/- 0.54 ng in milk. Further investigation of the active compounds in milk permitted the unequivocal identification of diazepam, both free and bound to a presumably protein carrier and, at least, three more benzodiazepine-like molecules. Their origin either from dietary sources or as a result of endogenous biosynthesis is still unclear.
通过放射免疫法在12名女性的血浆和乳汁以及9名男性的血浆中检测到了苯二氮卓类分子。所有受试者均未使用过苯二氮卓类药物。这些生物材料的浓度以每毫升地西泮当量表示，男性血浆中为2.54±0.74纳克；女性血浆中为2.20±0.35纳克，乳汁中为1.91±0.54纳克。对乳汁中活性化合物的进一步研究明确鉴定出了地西泮，包括游离的和与一种可能的蛋白质载体结合的，以及至少另外三种苯二氮卓类分子。它们的来源是饮食还是内源性生物合成仍不清楚。
