Potent HIV-1 protease inhibitors with antiviral activities in vitro.
作者信息
Sham H L, Betebenner D A, Wideburg N E, Saldivar A C, Kohlbrenner W E, Vasavanonda S, Kempf D J, Norbeck D W, Zhao C, Clement J J
机构信息
Abbott Laboratories, Pharmaceutical Discovery Division, Illinois 60064-3500.
出版信息
Biochem Biophys Res Commun. 1991 Mar 29;175(3):914-9. doi: 10.1016/0006-291x(91)91652-s.
PMID:2025263
Abstract
A series of novel difluoroketones with low molecular weight (less than 600 m.u.) and which are potent inhibitors of the HIV-1 protease (IC50 = 1.0 to 21 nM) were synthesized. These compounds also exhibited antiviral activity by inhibition of the cytopathic effect of HIV-1(3)B in MT-4 cells in vitro.
摘要
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