Eisen J S, Pike S H
Institute of Neuroscience, University of Oregon, Eugene 97403.
Neuron. 1991 May;6(5):767-76. doi: 10.1016/0896-6273(91)90173-w.
We examined the arrangement and development of identified neurons in zebrafish embryos homozygous for the mutation spt-1, which acts autonomously and specifically to alter the development of precursors of trunk segmented mesoderm, resulting in muscle-deficient myotomes. We found that the mutation alters the morphology, number, and arrangement of identified motoneurons. By transplanting identified motoneurons between wild-type and mutant embryos, we found that the effect of the mutation was nonautonomous. We suggest that the segmental arrangement and proper axonal development of motoneurons may result from interactions with segmented mesoderm.
我们研究了斑马鱼胚胎中 spt-1 突变纯合子中已识别神经元的排列和发育情况，该突变自主且特异性地改变躯干节段性中胚层前体的发育，导致肌节肌肉缺乏。我们发现该突变改变了已识别运动神经元的形态、数量和排列。通过在野生型和突变型胚胎之间移植已识别的运动神经元，我们发现该突变的影响是非自主性的。我们认为运动神经元的节段性排列和正确的轴突发育可能源于与节段性中胚层的相互作用。
