Kapelushnik J, Dubé I, Wilson P, Greenberg M
Department of Pediatrics, Hospital for Sick Children, Toronto, Ontario, Canada.
Cancer. 1991 Jun 1;67(11):2887-9. doi: 10.1002/1097-0142(19910601)67:11<2887::aid-cncr2820671130>3.0.co;2-f.
The authors report a case of acute lymphoblastic leukemia (ALL) with t(4;11) (q21;q23) occurring 9 months after treatment of osteogenic sarcoma. Cell surface marker and molecular analyses suggest early B lineage involvement. This is the first report, to the knowledge of the authors, of t(4;11) ALL arising after an osteogenic sarcoma. The observations of the authors support the possibility of a causal relationship between exposure to carcinogens and the occurrence of leukemia with t(4;11).
作者报告了1例骨肉瘤治疗9个月后发生的伴有t(4;11)(q21;q23)的急性淋巴细胞白血病(ALL)。细胞表面标志物和分子分析提示早期B系受累。据作者所知，这是首例骨肉瘤后发生的t(4;11) ALL报告。作者的观察结果支持接触致癌物与t(4;11)白血病发生之间存在因果关系的可能性。
