中间神经元在青霉素诱导的癫痫放电中的参与。
Participation of interneurons in penicillin-induced epileptic discharges.
作者信息
Domann R, Uhlig S, Dorn T, Witte O W
机构信息
Neurologische Klinik, Heinrich-Heine-Universität, Düsseldorf, Federal Republic Germany.
出版信息
Exp Brain Res. 1991;83(3):683-6. doi: 10.1007/BF00229848.
Interneurons of rat motor cortex in vivo and of rat hippocampal slices were studied during penicillin-induced epileptic discharges. Synchronous with pyramidal cells, they showed transient depolarizations similar to paroxysmal depolarization shifts in pyramidal cells. The transient depolarizations were followed by hyperpolarizing or depolarizing afterpotentials lasting 600 to 1200 ms. During the transient depolarizations and the afterdepolarizations the interneurons discharged with increased frequency. This may contribute to the enlarged and prolonged synaptic inhibitions following interictal discharges in pyramidal cells.
在青霉素诱发的癫痫放电期间，对大鼠运动皮层的中间神经元进行了体内研究，并对大鼠海马切片中的中间神经元进行了研究。与锥体细胞同步，它们表现出短暂的去极化，类似于锥体细胞中的阵发性去极化偏移。短暂去极化之后是持续600至1200毫秒的超极化或去极化后电位。在短暂去极化和去极化后阶段，中间神经元放电频率增加。这可能有助于锥体细胞发作间期放电后突触抑制的扩大和延长。
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