Dübel H P, Romaniuk P, Warnke H
Bereich Medizin (Charité), Humboldt-Universität zu Berlin.
Herz. 1991 Feb;16(1):55-9.
In detailed angiographic follow-up examinations in patients after heart transplantation, coronary artery-ventricular fistulas were observed in two of ten patients. In one patient, in the first postoperative year, 19 right ventricular biopsy procedures were performed obtaining a total of 71 tissue specimens and one year after transplantation, additionally, three specimens were obtained from the left ventricle. Coronary angiography demonstrated a fistula from the first anterior ventricular branch of the right coronary artery into the right ventricle (Figure 1) as well as a second smaller fistula between from a septal perforator of the left anterior descending artery into the left ventricle. At follow-up angiography two months later, the fistulas were unchanged in site and extent (Figure 2). Angiographically there was diffuse hypokinesis of the right ventricle and moderate tricuspid regurgitation. In the second patient, in the first year after transplantation, 20 right ventricular biopsy procedures were performed obtaining a total of 80 tissue specimens. One year after transplantation coronary angiography showed a fistula between a septal perforator of the left anterior descending artery into the right ventricle (Figure 3) which, two months later, was unchanged in morphology and, as in the first case, the size of the shunt was small. Angiographically, there was moderate tricuspid regurgitation and apical hypokinesis of the left ventricle. If a relationship between the fistulas and biopsies is postulated, from a total 196 biopsy procedures obtaining 748 tissue specimens, the rate of this complication would be calculated at 1.5%. It cannot be ruled out, however, that the fistulas had been congenitally present in the donor hearts.(ABSTRACT TRUNCATED AT 250 WORDS)
在心脏移植术后患者的详细血管造影随访检查中,10例患者中有2例观察到冠状动脉心室瘘。在1例患者中,术后第一年进行了19次右心室活检,共获取71个组织标本,移植后一年,又从左心室获取了3个标本。冠状动脉造影显示,右冠状动脉第一前室支有一瘘管通向右心室(图1),以及左前降支一个间隔穿支与左心室之间有第二个较小的瘘管。两个月后的随访血管造影显示,瘘管的部位和范围无变化(图2)。血管造影显示右心室弥漫性运动减弱及中度三尖瓣反流。在第二例患者中,移植后第一年进行了20次右心室活检,共获取80个组织标本。移植后一年冠状动脉造影显示左前降支一个间隔穿支与右心室之间有一瘘管(图3),两个月后,其形态无变化,且与第一例一样,分流较小。血管造影显示有中度三尖瓣反流及左心室心尖运动减弱。如果假定瘘管与活检之间存在关联,在总共196次活检获取748个组织标本的情况下,这种并发症的发生率将计算为1.5%。然而,不能排除瘘管在供体心脏中先天性存在的可能性。(摘要截短至250字)