Determination of the origin of nondisjunction in a 49,XXXXY male using hypervariable dinucleotide repeat sequences.
作者信息
Huang T H, Greenberg F, Ledbetter D H
机构信息
Institute for Molecular Genetics, Baylor College of Medicine, Houston, TX 77030.
出版信息
Hum Genet. 1991 Apr;86(6):619-20. doi: 10.1007/BF00201553.
PMID:2026425
Abstract
We present a patient with a 49,XXXXY chromosome constitution in whom the origin of the extra X chromosomes was determined by analysis of five polymorphic CA (or GT) dinucleotide repeat sequences. This class of DNA marker has recently been demonstrated to be hypervariable with heterozygosity values up to 80%. By polymerase chain reaction (PCR) analysis of the dinucleotide repeat length polymorphisms, we have shown that all four X chromosomes were of maternal origin.
摘要
Zotero 插件